ABC Transporters and Multidrug Resistance

Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

John Wiley & Sons, Jun 17, 2009 - Medical - 480 pages

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.

ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Contents

• PART I ABC PROTEINS AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE GENOME NORMAL TISSUE EXPRESSION PHYSIOLOG...: 15
• PART II ABC PROTEINS AND ONCOLOGY EXPRESSION DETECTION AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MA...: 119
• PART III ABC PROTEINS AND PATHOGENIC MICROORGANISMS: 177
• PART IV MULTIDRUG RESISTANCE MDR MODULATION THROUGH INHIBITION OF ABC TRANSPORTERS DESIGN OF INHIBITORS AN...: 239
• PART V BIOLOGICAL AND CLINICAL ASPECTS OF MULTIDRUG RESISTANCE THE ROLE OF THE TRANSPORTERS AT THE MAIN PRO...: 363
• PERSPECTIVES: 437
• INDEX: 441

About the author

Ahcéne Boumendjel is Professor of Medicinal Chemistry at the University of Grenoble School of Pharmacy, France.

Jean Boutonnat is an Assistant Professor and Hospital Practitioner at the Grenoble Medical School and Université Joseph Fourier of Grenoble, France.

Jacques Robert is Professor and Head of the Laboratory of Pharmacology of Anticancer Agents at Institut Bergonié and Université Victor Segalen Bordeaux 2, France.

Bibliographic information

• Title: ABC Transporters and Multidrug Resistance; Wiley Series in Drug Discovery and Development
• Editors: Ahcène Boumendjel, Jean Boutonnat, Jacques Robert
• Publisher: John Wiley & Sons, 2009
• ISBN: 047049512X, 9780470495124
• Length: 480 pages
• Subjects: Medical / Pharmacology; Science / Chemistry / General