A Practical Guide to Implementing Clinical Mass Spectrometry SystemsMass spectrometry is becoming increasingly popular in the field of therapeutic drug monitoring. The aim of this publication is to provide practical guidance for laboratories on the implementation of mass spectrometry into a clinical service where there might be limited expertise in the technique. This guidance is the author's personal recommendation based on over ten years' experience of clinical mass spectrometry. Throughout the text, examples are given to illustrate issues that a clinical laboratory might encounter. While some examples relate to the field of immunosuppressive drug monitoring, the issues are common and relevant to any clinical application. The guidance provided is also applicable to instrumentation made by any manufacturer. This practical guide covers instrument selection through business planning to installation, risk management and validation, and includes suggestions for future prospects for this developing field. |
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2011 ILM Publications acetonitrile adduct advisable air conditioning analyte of interest APCI source assay autosampler back-up CE marked chromatography clinical laboratories clinical market Clinical Mass Spectrometry co-eluting column cost cyclosporin dead volume detected division of International engineer ensure essential European Commission expertise flow Guide to Implementing hardware HPLC system immunoassay immunosuppressive drugs Implementing Clinical Mass injected installation instru instrument manufacturers internal standard International Labmate Limited ion of interest ion suppression ion trap LC–MS system maintain Mass Spectrometry Systems matrix metabolite methanol method validation methodology mobile phase molecule of interest MPAG mycophenolic acid Neil Leaver operate optimised option peak potential Practical Guide pump quantitation reagent replaced risk analysis risk management sample preparation Saturday Sunday Monday scan selection solvent specimen staff supply system specialists therapeutic drug monitoring trading division triple quadrupole instrument tubing UHPLC uninterruptible power supply users usually vitamin D whole blood