A Metabolic Approach to the Inherited Diseases of Purine and Pyrimidine Metabolism |
Contents
B The Metabolic Approach to Inherited Disease | 8 |
The Specific Goals of This Research | 11 |
Guanosine Monophosphate Synthetase and | 25 |
10 other sections not shown
Common terms and phrases
100 nanomoles purines adenine adenylate kinase ammonium sulfate aspartate bicarbonate buffer CALIFOR carbamyl phosphate chloride choreoathetosis DIEGO LIBRARY diphosphate Double reciprocal plots elution enzyme activity enzyme defect extracellular uridine fibroblast lysates fibroblasts Figure glutamine GMP synthetase activity guanine guanosine HPLC HPRT activity HPRT deficiency human enzyme hyperuricemia hypoxanthine incubation inhibition inosine intact cells intact fibroblasts kinetic labeled Lesch-Nyhan syndrome LIBRARY DIEGO LIBRARY UNIVERSITY Linearity metabolic approach metabolic disease research metabolic pathways metabolite minutes mutant enzymes nucleotides ORNIA orotic acid orotic aciduria orotidine monophosphate Patient S.M. perchloric acid phosphoribosyl pyrophosphate phosphoribosyl transferase picomoles possible precursors protein pulsing purified purine and pyrimidine purine bases pyrimidine compounds pyrimidine metabolism quantitated reaction RNIA SAN DIEGO UNIVERSITY SITY substrate symptoms tion triphosphate UNIV UNIVERSITY DIEGO UNIVERSITY LIBRARY UNIVERSITY SAN DIEGO UNIVERSITY UNIVERSITY uracil uric acid uridine monophosphate xanthine xanthosine zyme