Advances in Radiation Oncology in Lung Cancer

Branislav Jeremic

Springer Science & Business Media, Sep 18, 2011 - Medical - 843 pages

This is the second, completely updated edition of a comprehensive book in which many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings. The first three sections cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including IMRT, IMAT, cyber knife treatment, and tomotherapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer.

Contents

• Part I Basic Science of Lung Cancer: 2
• 310 Molecular Biology and Genetics of Lung Cancer: 3
• 260 Angiogenesis and Lung Cancer: 17
• Part II Clinical Investigations: 42
• 206 Interventional Pulmonology: 43
• 304 Pathology of Lung Cancer: 53
• 267 Radiologic Imaging of Lung Cancer: 63
• 323 PETCT for Staging and Diagnosis of Lung Cancer: 75
• 261 Surgical Staging of Lung Cancer for Advances in Radiation Oncology of Lung Cancer: 89
• Part III Basic Treatment Considerations: 100
• 318 Lung Cancer Surgery: 101
• 250 Radiation Response of the Normal Lung Tissue and Lung Tumors: 119
• 268 Radiation Time Dose and Fractionation in the Treatment of Lung Cancer: 129
• 302 3D Radiation Treatment Planning and Execution: 142
• A Clinical Perspective: 157
• 300 PET and PETCT in Treatment Planning: 173
• 231 Target Volume Definition in NonSmall Cell Lung Cancer: 187
• 251 The Radiation Target in SmallCell Lung Cancer: 201
• 278 Radiation Sensitizers: 213
• 288 Radioprotectors and Chemoprotectors in the Management of Lung Cancer: 223
• 307 Systemic Therapy for Lung Cancer for the Radiation Oncologist: 247
• Theoretical Considerations and Biological Premises: 267
• 272 Radiotherapy and Second Generation Drugs: 274
• 269 Radiotherapy and Third Generation Concurrent Chemotherapy Agents: 291
• Part IV Current Treatment Strategies In EarlyStage NonSmall Cell Lung Cancer: 313
• 207 Conventional Radiation Therapy in Early Stage Nonsmallcell Lung Cancer: 315
• 258 Stereotactic Ablative Radiotherapy for Early Stage Lung Cancer: 342
• 315 Postoperative Radiotherapy for NonSmall Cell Carcinoma: 363
• 220 PDTLung: 371
• 230 The Role of Radiofrequency Ablation in the Treatment of Stage 1 NonSmall Cell Lung Cancer: 381
• Part V Current Treatment Strategies in Locally Advanced NonSmall Cell Lung Cancer: 396
• 298 Lung Dose Escalation: 399
• 232 Radiochemotherapy in Locally Advanced NonsmallCell Lung Cancer: 409
• 306 TriModality Therapy in Locally Advanced NonSmallCell Lung Cancer: 432
• 252 Prophylactic Cranial Irradiation: 445
• 316 Palliative External Beam Thoracic Radiation Therapy of NonSmall Cell Lung Cancer: 453
• Methodology Electrons or Brachytherapy Clinical Experiences and LongTerm Institutional Results: 460
• 311 Brachytherapy for Lung Cancer: 477
• Part VI Current Treatment Strategies in Small Cell Lung Cancer: 489
• 253 LimitedDisease SmallCell Lung Cancer: 491
• 208 Radiation Therapy in Extensive Disease Small Cell Lung Cancer: 505
• 270 Prophylactic Cranial Irradiation in SmallCell Lung Cancer: 513
• Part VII Treatment in Specific Patient Groups and Other Settings: 521
• 254 Radiation Therapy for Lung Cancer in Elderly: 523
• 255 Radiation Therapy for Recurrent Disease: 543
• 275 Radiation Therapy for Metastatic Disease: 560
• 313 Advances in Supportive and Palliative Care for Lung Cancer Patients: 575
• Part VIII TreatmentRelated Toxicity: 594
• Part IX Quality of Life Studies and Prognostic Factors: 659
• 259 Quality of Life Outcomes in Radiotherapy of Lung Cancer: 660
• 308 Prognostic Factors in Lung Cancer: 675
• Part X Technological Advances in Lung Cancer: 689
• 283 IntensityModulated Radiation Therapy and VolumetricModulated Arc Therapy for Lung Cancer: 690
• The CyberKnife: 715
• 277 Advances in Radiation Oncology of Lung Cancer: 725
• 287 ImageGuided Radiotherapy in Lung Cancer: 735
• State of the Science: 743
• 257 Carbon Ion Radiotherapy in HypoFractionation Regimen and Single Dose for Stage I NonsmallCell Lung Cancer: 753
• Part XI Biological Advances in Lung Cancer: 764
• Focus on Pemetrexed and NabPaclitaxel Abraxane: 765
• 312 Novel Targeted Agents and Radiopharmaceuticals in Lung Cancer: 773
• Part XII Clinical Research in Lung Cancer: 791
• 296 Translational Research in Lung Cancer: 792
• Why We Failed?: 809
• 282 Pitfalls in the Design Analysis Presentation and Interpretation of Randomized Clinical Trials: 819
• 299 New Directions in the Evaluation and Presentation of Clinical Research in Lung Cancer: 827
• Index: 837

Bibliographic information

• Title: Advances in Radiation Oncology in Lung Cancer; Medical Radiology; Radiation Oncology
• Editor: Branislav Jeremic
• Edition: 2, illustrated, revised
• Publisher: Springer Science & Business Media, 2011
• ISBN: 3642199259, 9783642199257
• Length: 843 pages
• Subjects: Medical / Allied Health Services / Imaging Technologies; Medical / Biochemistry; Medical / Clinical Medicine; Medical / Oncology / General; Medical / Pulmonary & Thoracic Medicine; Medical / Radiology, Radiotherapy & Nuclear Medicine; Medical / Surgery / Cardiothoracic