An Essential Guide to Cardiac Cell TherapySparked by a new understanding that the development of tissues is not restricted to the embryonic phase of development and thus that regeneration of tissues can occur in adults, the emerging field of stem cell therapy has grown exponentially in the last several years. Crucially, the research and findings associated with stem cell research overlap into many other areas, such as basic cell biology, molecular biology and hematology, and the proliferation of clinical studies involving stem cell research is gradually crossing over into the practice of medicine as many patients may become candidates for such novel treatments. As a response to this, Guide to Cardiac Cell Therapy is a comprehensive but understandable resource that makes this exciting field accessible to clinical practitioners. Bridging the gap between basic science and practice, it is a useful introduction to the area as well as a cutting-edge update of the developments in stem cell therapy as applied to cardiovascular disease. |
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acute myocardial infarction adult stem cells angina angiogenesis angiogenic angioplasty animal models assessment autologous Autologous skeletal myoblast blood flow BMMNCs bone marrow cells bone marrow-derived capillary cardiac myocytes cardiac repair cardiac stem cells cardiomyocytes Cardiovasc cardiovascular catheter cell delivery cell types cell-based cellular chronic Circ Res Circulation clinical trials Coll Cardiol collateral contractile culture differentiation electromechanical mapping embryonic stem cells endocardial endothelial cells endothelial progenitor cells engraftment enhanced EPCs ESCs expression fibroblast fluorescent follow-up function fusion G-CSF gene growth factor hematopoietic stem cells HSCs human implantation improvement increased infarcted myocardium infusion intracoronary intramyocardial injection left ventricular LVEF markers mesenchymal lineage mesenchymal stem cells mice mononuclear cells mouse MSCs myocar myocardial ischemia myocardium neovascularization occlusion patients percutaneous pericytes peripheral blood phenotype postinfarction potential preclinical precursors protein remodeling skeletal myoblast transplantation stem cell therapy stromal cells studies therapeutic tion tissue trans transdifferentiation transendocardial ventricle vessels viability vitro vivo