Bioengineering Approaches to Pulmonary Physiology and MedicineM.C.K. Khoo As the current millennium steams towards a close, one cannot help but look with amazement at the incredible amount of progress that has been achieved in medicine in just the last few decades. A key contributing factor to this success has been the importation and blending of ideas and techniques from disciplines outside the traditional borders of medical science. In recent years, the most well-known example is the cross-pollination between molecular biology and medicine. Advances driven by this potent combination have spawned the vision of a future where cures based on gene therapy become commonplace. Yet, as we continue our search for "magic bullets" in the quest to eradicate disease, it important to recognize the value of other less-heralded interdisciplinary efforts that have laid a large part of the foundation of present-day medicine. In pulmonary medicine, the contribution from the bioengineers (a diverse collection of individuals cross-bred to various degrees in mathematical modeling and experimental physiology) has been larger and more sustained than in many other medical specialties. It is easy to point to the vast array of ventilators, blood-gas analyzers, oximeters, pulmonary function devices, and respiration monitors that are present in any modern clinical setting as solid evidence of the successful synergy between engineering science and pulmonary medicine. However, one must not forget the less tangible, but perhaps more important, contributions that have been derived from mathematical modeling and computer simulation, without which many of these modern instruments would not have come into existence. |
Contents
A Multipurpose Model for Studying | 25 |
System | 51 |
Estimation of Changes in Chemoreflex Gain and Wakefulness Drive during | 65 |
Realistic Computational Models of Respiratory Neurons and Networks | 77 |
Synaptic Plasticity and Respiratory Control | 93 |
Dysrhythmias of the Respiratory Oscillator | 115 |
Assessing Deterministic Structures in Physiological Systems Using Recurrence | 137 |
Contents | 149 |
Fractal Noise in Breathing | 161 |
Nonlinear Control of Breathing Activity in Early Development | 175 |
Possible Fractal andor Chaotic Breathing Patterns in Resting Humans | 187 |
Heterogeneity of Pulmonary Perfusion Characterized by Fractals and Spatial | 197 |
The Temporal Dynamics of Acute Induced Bronchoconstriction | 213 |
Understanding Pulmonary Mechanics Using the Forced Oscillations | 227 |
Index 255 | 239 |
Other editions - View all
Bioengineering Approaches to Pulmonary Physiology and Medicine M.C.K. Khoo No preview available - 2010 |
Bioengineering Approaches to Pulmonary Physiology and Medicine M. C. K. Khoo No preview available - 2014 |
Common terms and phrases
activity afferent airway and tissue algorithm alveolar capsule amplitude analysis apnea Appl arousal attractor-cycle behavior blood flow brainstem breathing pattern bronchoconstriction carotid bodies central changes chemoreceptors chemoreflex CO₂ components correlation cycle deterministic distribution dynamic dysrhythmia effect end-tidal equations estimated experimental exponent fetal breathing Figure fluctuations fractal dimension frequency function hypercapnia hypoxia hypoxic impedance increase inhomogeneities input Khoo L/min limit-cycle linear lung Lutchen Lyapunov exponents measured mechanisms medullary membrane neural neurons noise nonlinear normal optimal PaCO2 panel parameters PCO2 periodic breathing perturbations PETCO2 Physiol physiological potential power spectrum predicted pressure properties pulmonary random rebreathing recurrence plots rescaled range respiration respiratory control respiratory oscillator respiratory pattern respiratory rhythm respiratory system signal simulated singular point sleep spatial spectral stable synaptic plasticity threshold tidal volume upper airway values variability ventilation ventilatory response wakefulness drive