Biopharmaceuticals: Biochemistry and BiotechnologyThe latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with 'newer' pharmaceutical substances derived from genetic engineering or hybridoma technology. This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery. |
Contents
The age of biopharmaceuticals | 5 |
Traditional pharmaceuticals of biological origin | 12 |
Further reading | 40 |
Copyright | |
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additional administration agents amino acid animal antibiotics antigen application approved binding biological activity biopharmaceutical Biotechnology blood cancer cell bank cell lines cell types cellular Chapter chromatography clinical trials clot coli contains cytokines diabetes disease display domain downstream processing drug effects entails enzyme erythropoietin expression factor VIII Figure filtration final product function gene therapy genetic genome glycoprotein glycosylation GM-CSF gonadotrophin growth factor Haemophilia hepatitis hormone human immunological induce infection inhibin inhibit initial insulin interferon intracellular kinase levels lymphocytes macrophages manufacture membrane microbial molecular mass molecules monoclonal antibodies mRNA murine neurons neurotrophic factors normally pathogens patients peptide pharmaceutical plasma plasmid platelet polypeptide potential preparations promote protein proteolytic purified receptor recombinant regulatory residues role sequence serum signal transduction specific stimulating structure subsequent substances synthesis Table therapeutic tissue toxicity treatment tumour undertaken vaccine various vector viral virus vitro