Bioreversible Carriers in Drug Design: Theory and ApplicationEdward B. Roche |
Contents
Design of Bioreversible Drug | 13 |
Chemical Drug Delivery Systems | 95 |
Application of Physical Organic Concepts | 121 |
Copyright | |
7 other sections not shown
Common terms and phrases
action activity administration agents allopurinol amide amines amino acid aminopeptidase appear application approach aqueous solution availability biological bioreversible blood-brain barrier brain brush border Bundgaard calculations carrier catalyzed cell Chem chemical Chemistry compounds concentrations considered containing copolymers decreased degradation derivatives derivatization determined discussed drug delivery systems effects endothelium enhanced enzymatic enzyme ester esterase example experiments factors Figure formulation function half-life human hydrolysis important improve increase indicate intestinal involved lability levels limited liver mechanism membrane methyl moiety molecule N-Mannich bases neutral observed obtained organization parameters parent drug Pharm Pharmaceutical physical model plasma polymers potential prepared present problem prodrug properties recently receptor relative release Scheme selective showed shown similar solubility solution specific stability structure studies surface Table therapeutic tissue transport University values various vidarabine vitro vivo water-soluble