Cell TherapyY. Ikeda Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy. All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy. The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world. The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy. |
Contents
Breaking Immunological Tolerance to Tumor Cells as a Novel | 3 |
Adoptive Immunotherapy of Human Diseases with AntigenSpecific | 29 |
Adoptive Transfer of Polyclonal EBVSpecific Cytotoxic TCell Lines | 45 |
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32D cells Acad Sci USA activity acute promyelocytic leukemia allogeneic antibody antigen recognized assay autologous bone marrow donor bone marrow transplantation cancer CD34+ cells CD4+ T cells CD8+ cDNA cell line chemotherapy clinical cord blood banks cord blood transplants CTL lines culture cytokines cytotoxic T lymphocytes dendritic cells differentiation dose EBV-specific CTL effects engraftment epitopes Epstein-Barr virus ex vivo ex vivo expansion expanded cells expression G-CSF gene therapy gene transfer GVHD hematopoietic cells hematopoietic progenitors hematopoietic stem cells HSCs immune responses Immunol induce infection infusion Keio University leukemic ligand lymphoma melanoma melanoma antigens minor H antigens molecules mouse murine myeloid Natl Acad Sci neutrophil Notch signaling patients PBMCs peptide peripheral blood Proc Natl Acad progenitor cells proteins receptor registries relapse retroviral Rosenberg Sakaguchi specific studies T-cell target transcription transduced transduced cells tumor tumor antigens tumor cells vector viral vitro