Cerebral Microbleeds: Pathophysiology to Clinical PracticeDavid J. Werring Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment. |
Contents
| 1 | |
2 Detection of cerebral microbleeds | 13 |
3 Susceptibilityweighted imaging | 22 |
4 Defining and mapping cerebral microbleeds | 34 |
5 Cerebral microbleed mimics | 44 |
6 Histopathology of cerebral microbleeds | 49 |
7 Risk factors for cerebral microbleeds | 65 |
8 Relationship of cerebral microbleeds to other imaging findings | 71 |
12 Cerebral microbleeds in relation to cerebral amyloid angiopathy | 109 |
13 Cerebral microbleeds and Alzheimers disease | 117 |
14 Cerebral microbleeds in relation to brain trauma | 125 |
15 Cerebral microbleeds in CADASIL | 135 |
16 Miscellaneous conditions associated with cerebral microbleeds | 142 |
17 Cerebral microbleeds and cognitive impairment | 152 |
18 Other clinical manifestations of cerebral microbleeds | 159 |
19 Cerebral microbleeds and antithrombotic treatment | 165 |
Other editions - View all
Cerebral Microbleeds: Pathophysiology to Clinical Practice David J. Werring No preview available - 2011 |
Common terms and phrases
acute ischemic stroke AJNR Alzheimer's disease analysis aneurysms antiplatelet antithrombotic arteries arterioles arteriopathy associated basal ganglia bleeding blood pressure brain microbleeds CADASIL cause cerebral amyloid angiopathy cerebral hemorrhage cerebral microbleed CMB cerebral microbleeds cerebrovascular disease chronic CMBs cognitive impairment cohort Cordonnier correlation cortical cortico-subcortical deposition detection diffuse distribution field strength gradient-echo gradient-recalled echo GRE sequences Greenberg SM hematomas hemorrhagic stroke hemosiderin histological histopathological hypertension increased intracerebral hemorrhage ischemic stroke lacunar infarcts Lee SH leukoaraiosis lobar CMBs magnetic resonance imaging markers microaneurysms microbleeds in patients microhemorrhages moyamoya multiple CMBs mutations neuroimaging Neurology Neuroradiol number of CMBs pathology patients with CMBs phase population presence of CMBs prevalence of CMBs radiological reported risk factors Roob G Rotterdam Scan Study signal loss small vessel disease spontaneous subcortical susceptibility-weighted imaging symptomatic thalamus thrombolysis tion tissue TMBs vasculopathy Vernooij MW vessel wall white matter white matter lesions