Chronic Pain and AddictionMichael R. Clark, Glenn J. Treisman The relationship between chronic pain and addiction Patients with chronic pain understandably seek relief from their distress and discomfort, but many medications that alleviate pain are potentially addictive, and most chronic pain conditions only have a temporary response to opiate analgesic drugs. This volume reviews the fundamental topics that underlie the complex relationships of this controversial domain. The authors review behavioral models and practical methods for understanding and treating chronic pain and addiction including methods to formulate patients with complex comorbidity and screen patients with chronic pain for addictive liability. Finally, the authors describe the current findings from clinical and basic science that illuminate the role of opiates, cannabinoids and ketamine in the treatment of chronic pain. Up to date and comprehensive, this book is relevant to all professionals engaged in the care of patients with chronic pain or addiction and all others interested in these contemporary issues, particularly non-clinicians seeking clarity in the controversy over the best approach to patients with chronic pain. |
Contents
From Stigmatized Neglect to Active Engagement | 1 |
A Behaviorist Perspective | 8 |
Addiction and Brain Reward and Antireward Pathways | 22 |
Diagnostic and Clinical Challenges | 61 |
Optimizing Treatment with Opioids and Beyond | 92 |
Screening for Abuse Risk in Pain Patients | 113 |
Cannabinoids for Pain Management | 125 |
Ketamine in Pain Management | 139 |
| 162 | |
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aberrant addictive drugs administration alfentanil amygdala analgesia analgesic animal models assessment associated brain reward brain stimulation reward buprenorphine cancer pain cannabinoids cannabis central chronic noncancer pain chronic pain chronic pain patients Clin J Pain clinical clinicians cocaine comorbidities craving crossover depression dopamine dose double-blind drug abuse drug addiction drug-seeking behavior effects of ketamine efficacy evaluation factors fibromyalgia function Gardner hyperalgesia increased intravenous ketamine Koob GF Medicine methadone mg/kg misuse morphine nabilone neural neurons neuropathic pain Neurosci nicotine NMDA receptor nucleus accumbens opiate opioid abuse opioid analgesics opioid therapy oral Pain and Addiction pain management pain relief Pain Symptom Manage pain syndrome patients receiving patients with chronic Pharmacol physical dependence physicians placebo placebo-controlled potential predict prescribed opioids prescription problems rats receptor antagonists reinforcement relapse reward circuitry risk seeking behavior self-administration studies substance use disorders Synapse tion treat treatment of chronic trial ventral tegmental area vulnerability