Clinical Pharmacokinetics: Concepts and ApplicationsSince pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading. Compatibility: BlackBerry OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile™ Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC |
Contents
Why Clinical Pharmacokinetics? | 1 |
ABSORPTION AND DISPOSITION KINETICS | 9 |
Basic Considerations | 11 |
Copyright | |
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absorbed absorption achieved acid activity administration altered amount apparent approach approximately average binding bioavailability blood body bolus dose calculated Chap Clin consider constant creatinine curve decline decrease depends determined dialysis disease dosage dose dosing interval drug concentration effect elimination enzyme equal estimate example excretion expected extraction ratio factors fraction frequently given greater half-life hepatic Hours increase infusion initial intestine kinetics L/hr less limit liver mean measured membranes metabolism metabolite mg/L needed normal observed obtained occurs oral parameters patient pharmacokinetics phase plasma concentration plasma proteins plateau plot problem produce reach regimen relationship relative remaining renal clearance renal function respectively response shown shows single steady steady-state STUDY subjects Table theophylline therapeutic tissue toxicity turnover unbound urine usual variability varies volume of distribution weight