Current Concepts in Drug Metabolism and ToxicologyThis new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
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Contents
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The Keap1Nrf2 Cell Defense Pathway A Promising Therapeutic Target? | 43 |
Animal Models of Idiosyncratic Drug Reactions | 81 |
Recent Advances and Clinical Aspects | 137 |
Arylamine NAcetyltransferases from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention | 169 |
Other editions - View all
Current Concepts in Drug Metabolism and Toxicology, Volume 63 Gabrielle M. Hawksworth Limited preview - 2012 |
Common terms and phrases
acetylation acid activity of Nrf2 agranulocytosis allele amodiaquine animal models antibodies antioxidant arylamine N-acetyltransferase assay associated autoimmunity binding Biochemical Boukouvala cardiac cardiomyocytes cell lines cellular Clinical Pharmacology clopidogrel compounds cysteine cytochrome P450 demonstrated differentiation DILI disease dose Drug Metabolism drug-induced effects embryonic stem cells enzymes felbamate functional genetic genomic genotype hepatic hepatocyte-like cells hepatocytes hepatotoxicity hESC human embryonic stem human NAT1 identified IDRs immune response increase induced pluripotent inhibition inhibitor interaction isoniazid Journal of Biological Keap1 levels liver injury mechanism membrane Metabolism and Disposition mice mitochondrial Molecular molecules mouse NAT enzymes NAT2 neuronal neutrophils Nrf2 oxidative stress pathway patients penicillamine Pharmaceutical Pharmacogenetics Pharmacology phenotype pluripotent pluripotent stem cells polymorphisms potential predict protein reactions reactive metabolite receptor regulation Research in Toxicology role Sciences skin rash specific studies substrate target Therapeutics tion tissue toxicity Toxicology transcription factor transporters treatment Uetrecht vitro vivo xenobiotic Zhang