Current Indications for Growth Hormone TherapyPeter C. Hindmarsh Breaking new ground in terms of scientific analysis, this book addresses the question of who benefits most from treatment with recombinant human growth hormone. Outlined at the beginning of this book are the principles of evidence-based medicine along with a critical appraisal of the statistical issues that lie at the center of growth hormone trials. Each chapter reviews the current state of knowledge on the use of growth hormone in conditions ranging from Turner syndrome through other syndromes of intrauterine growth retardation to the short normal child, also highlighting issues that remain to be addressed in further research. Evaluating therapies in terms of efficacy and safety or the health benefit for the individual or society as a whole are rarely approached in pediatric endocrinology and for this reason a special chapter on health economic evaluation is included. This book is of interest and offers practical help to pediatricians and endocrinologists. |
Contents
EDV1999001001 | 1 |
EDV1999001013 | 13 |
EDV1999001033 | 33 |
EDV1999001055 | 55 |
EDV1999001068 | 68 |
EDV1999001087 | 87 |
EDV1999001094 | 94 |
EDV1999001102 | 102 |
EDV1999001118 | 118 |
EDV1999001128 | 128 |
| 157 | |
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Common terms and phrases
achondroplasia Acta Paediatr adult height analysis Arch Dis Child assessment bone age catch-up growth children with CRF children with preterminal Clin Endocrinol Metab clinical trials cm/year costs and benefits doses of GH Drummond economic evaluation effect of GH estrogen evidence factor final height Genet GH deficiency GH dose GH secretion GH supplementation GH therapy GH treatment GnRHa growth failure growth hormone deficiency growth hormone therapy growth hormone treatment growth rate growth response growth retardation growth velocity height SDS height velocity Hindmarsh PC Horm Res human growth hormone hypochondroplasia idiopathic short stature IGF-I increase intervention IU/kg/week levels mean measure metabolic acidosis Noonan syndrome onset outcome patients Pediatr potential preterminal CRF pubertal development puberty randomized Ranke MB relative renal osteodystrophy reported response to GH rhGH serum short children significant skeletal dysplasia statistical technologies therapeutic treated treatment effect Turner syndrome