Edhf 2002Paul M. Vanhoutte Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. EDHF 2002 is based on the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations. It will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases. |
Contents
1 Potassium channels and membrane potential in vascular endothelial and smooth muscle cells | 1 |
2 Possible contribution of CLCA1 to calciumactivated chloride channels in murine smooth muscle cells | 13 |
3 Trafficking and transduction functions of the Na pump in vascular smooth muscle cells | 20 |
4 Isoforms of the NaKATPase | 27 |
5 Calcium sparks and membrane potential | 35 |
release of an endotheliumderived hyperpolarizing factor distinct from that released by | 47 |
7 Mechanical stimulation increases the activity and expression of cytochrome P450 2C in porcine coronary artery endothelial | 56 |
8 Important role of hydrogen peroxide as an endotheliumderived hyperpolarizing factor in animals and humans | 63 |
26 Endotheliumdependent depolarization and its implications for endotheliumderived hyperpolarizing factor | 199 |
27 Role of gap junctions in EDHFmediated relaxation response in human subcutaneous resistance arteries | 205 |
28 Permissive role of cAMP in the mediation of relaxations initiated by endothelial hyperpolarization | 211 |
29 Myoendothelial gap junctionsthe critical link for endotheliumderived hyperpolarizing factor | 223 |
30 Longitudinal spread of agonistevoked hyperpolarization in the rat mesenteric artery | 234 |
31 Effect of HEPES on EDHF responses in porcine coronary and rat mesenteric arteries | 239 |
32 Quantification of the amount of potassium released by cultured porcine coronary endothelial cells stimulated by bradykinin | 248 |
33 The intensity of agoniststimulation influences the mechanism for relaxation in rat mesenteric arteries | 256 |
9 Altered calcium dynamics do not account for the attenuation of EDHFmediated dilatations in the middle cerebral artery of | 70 |
influence on nitric oxide synthaseand cyclooxygenaseindependent renal vasodilatation basal | 78 |
11 Urocortininduced relaxations of the rat coronary artery | 87 |
12 Nitric oxide is the only EDHF released by the endothelium in lymphatic vessels of the guineapig mesentery | 93 |
13 Role of EDHF in vascular tone in vivo | 101 |
14 Endotheliumderived hyperpolarizing factormyoendothelial gap junctions and hypertension | 108 |
15 Improvement of agerelated impairment of endotheliumdependent hyperpolarization by reninangiotensin system blockade | 117 |
16 Characterization of endotheliumderived hyperpolarizing factormediated relaxation of small mesenteric arteries from | 124 |
17 Endotheliumdependent responses in small arteries isolated from normal and preeclamptic pregnant women | 132 |
18 Free radical species and endothelium dysfunction during deoxycorticosteronesalt induced hypertension | 139 |
19 EDHF involvement in skin pressureinduced vasodilatation | 151 |
20 Nacetylcysteine and immobilization stress attenuate dysregulation of the endotheliumdependent coronary vascular tone | 156 |
22 Estrogen substitution restores the basal influence of nitric oxide and endotheliumderived hyperpolarizing factor on | 174 |
23 Ascorbate inhibits EDHF in the bovine eye but not in the porcine coronary artery | 181 |
24 Gabexate mesilate inhibits endotheliumdependent relaxation but causes endotheliumindependent relaxation of rat blood | 188 |
25 Mechanisms underlying basal vascular tone in the guineapig mesenteric arterioles | 193 |
35 The role of KCa in endothelial cell hyperpolarization and endotheliumdependent relaxation in the rabbit aorta | 274 |
36 The contribution of Dtubocurarine and apaminsensitive potassium channels to endotheliumderived hyperpolarizing factor | 283 |
37 Ouabain blocks EDNOmediated relaxation in mesenteric veins and EDHFmediated relaxation in mesenteric arteries of the | 297 |
38 Inhibitors of EDHFevoked responses and the calcium signal in endothelial cell of mesenteric artery | 304 |
39 Roles of the inwardrectifier K channel and Na K ATPase in the hyperpolarization to K in rat mesenteric arteries | 309 |
40 Importance of intracellular concentration of sodium in the relaxation of rat isolated mesenteric arteries by potassium | 318 |
1415epoxyeicosa 5Zmonoenoic | 325 |
42 Local release of EDHF initiates a conducted dilatation but is not the upstream mediator in arterioles of the hamster | 332 |
function of astrocytic epoxyeicosatrienoic acids in the | 341 |
44 1112EETs hyperpolarize human platelets | 349 |
45 Epoxyeicosatrienoic acid activates cloned BKCa channel subunit through ADPribosylation of the Gprotein | 356 |
46 Different role of epoxyeicosatrienoic acids EET1112 in EDHFmediated relaxation in small porcine coronary and pulmonar | 366 |
the take home message | 371 |
References | 376 |
417 | |
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Common terms and phrases
abolished acetylcholine acid action activity addition apamin application arginine arterioles blocked blood vessels bradykinin Ca2+ calcium caused changes channels charybdotoxin combination compared concentration conductance containing contracted cytochrome P450 decreased depolarization determined diameter dilatation EDHF EETs effect endothelial cells endothelium endothelium-dependent et al evoked experiments expressed extracellular factor females Figure flow glucose groups human hyperpolarization hypertension iberiotoxin important increase incubation indicate indomethacin induced inhibited inhibitor involved isolated K+ channels levels maximal mean measured mechanism mediated membrane potential mesenteric arteries mice myoendothelial gap junctions NAME observed obtained ouabain peptide perfused phenylephrine physiological porcine coronary artery potassium preparations presence present study pressure produced protein pump recorded reduced relaxation release response resting rings role shown signal significant significantly smooth muscle cells solution specific stimulation stress subunit suggest tissue tone treatment tubocurarine University values vascular vascular smooth muscle vasodilatation vessels