Edhf 2002

Front Cover
Paul M. Vanhoutte
CRC Press, Nov 29, 2001 - Medical - 456 pages
Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. EDHF 2002 is based on the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations. It will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.
 

Contents

1 Potassium channels and membrane potential in vascular endothelial and smooth muscle cells
1
2 Possible contribution of CLCA1 to calciumactivated chloride channels in murine smooth muscle cells
13
3 Trafficking and transduction functions of the Na pump in vascular smooth muscle cells
20
4 Isoforms of the NaKATPase
27
5 Calcium sparks and membrane potential
35
release of an endotheliumderived hyperpolarizing factor distinct from that released by
47
7 Mechanical stimulation increases the activity and expression of cytochrome P450 2C in porcine coronary artery endothelial
56
8 Important role of hydrogen peroxide as an endotheliumderived hyperpolarizing factor in animals and humans
63
26 Endotheliumdependent depolarization and its implications for endotheliumderived hyperpolarizing factor
199
27 Role of gap junctions in EDHFmediated relaxation response in human subcutaneous resistance arteries
205
28 Permissive role of cAMP in the mediation of relaxations initiated by endothelial hyperpolarization
211
29 Myoendothelial gap junctionsthe critical link for endotheliumderived hyperpolarizing factor
223
30 Longitudinal spread of agonistevoked hyperpolarization in the rat mesenteric artery
234
31 Effect of HEPES on EDHF responses in porcine coronary and rat mesenteric arteries
239
32 Quantification of the amount of potassium released by cultured porcine coronary endothelial cells stimulated by bradykinin
248
33 The intensity of agoniststimulation influences the mechanism for relaxation in rat mesenteric arteries
256

9 Altered calcium dynamics do not account for the attenuation of EDHFmediated dilatations in the middle cerebral artery of
70
influence on nitric oxide synthaseand cyclooxygenaseindependent renal vasodilatation basal
78
11 Urocortininduced relaxations of the rat coronary artery
87
12 Nitric oxide is the only EDHF released by the endothelium in lymphatic vessels of the guineapig mesentery
93
13 Role of EDHF in vascular tone in vivo
101
14 Endotheliumderived hyperpolarizing factormyoendothelial gap junctions and hypertension
108
15 Improvement of agerelated impairment of endotheliumdependent hyperpolarization by reninangiotensin system blockade
117
16 Characterization of endotheliumderived hyperpolarizing factormediated relaxation of small mesenteric arteries from
124
17 Endotheliumdependent responses in small arteries isolated from normal and preeclamptic pregnant women
132
18 Free radical species and endothelium dysfunction during deoxycorticosteronesalt induced hypertension
139
19 EDHF involvement in skin pressureinduced vasodilatation
151
20 Nacetylcysteine and immobilization stress attenuate dysregulation of the endotheliumdependent coronary vascular tone
156
22 Estrogen substitution restores the basal influence of nitric oxide and endotheliumderived hyperpolarizing factor on
174
23 Ascorbate inhibits EDHF in the bovine eye but not in the porcine coronary artery
181
24 Gabexate mesilate inhibits endotheliumdependent relaxation but causes endotheliumindependent relaxation of rat blood
188
25 Mechanisms underlying basal vascular tone in the guineapig mesenteric arterioles
193
35 The role of KCa in endothelial cell hyperpolarization and endotheliumdependent relaxation in the rabbit aorta
274
36 The contribution of Dtubocurarine and apaminsensitive potassium channels to endotheliumderived hyperpolarizing factor
283
37 Ouabain blocks EDNOmediated relaxation in mesenteric veins and EDHFmediated relaxation in mesenteric arteries of the
297
38 Inhibitors of EDHFevoked responses and the calcium signal in endothelial cell of mesenteric artery
304
39 Roles of the inwardrectifier K channel and Na K ATPase in the hyperpolarization to K in rat mesenteric arteries
309
40 Importance of intracellular concentration of sodium in the relaxation of rat isolated mesenteric arteries by potassium
318
1415epoxyeicosa 5Zmonoenoic
325
42 Local release of EDHF initiates a conducted dilatation but is not the upstream mediator in arterioles of the hamster
332
function of astrocytic epoxyeicosatrienoic acids in the
341
44 1112EETs hyperpolarize human platelets
349
45 Epoxyeicosatrienoic acid activates cloned BKCa channel subunit through ADPribosylation of the Gprotein
356
46 Different role of epoxyeicosatrienoic acids EET1112 in EDHFmediated relaxation in small porcine coronary and pulmonar
366
the take home message
371
References
376
Index
417
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