Endocrine Disrupters and Carcinogenic Risk AssessmentLech Chyczewski, Jacek Niklinski, Eric Pluygers This work is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of biologically-based risk assessment, as developed form physiologically-based toxicokinetic models. The analysis of this material is proposed as the novel parameters for developing biologically-based models of carcinogenesis, considered to be more relevant to risk assessment than traditional approaches. |
Contents
Preface Lech Chyczewski Jacek Niklinski and Eric Pluygers | 1 |
Risk Assessment and Risk Management in the European Community and in | 9 |
Some Points of Interest for a Discussion | 15 |
An Overview Curtis Travis | 28 |
Approaches Issues and Uncertainties | 37 |
Human Exposure to Endocrine Disrupters an Overview Nicolás Olea | 49 |
Carcinogenic Risk Assessment | 62 |
An Overview with Special Reference to Endocrine Disrupting | 72 |
Observations as to Male Fertility in the Flemish Environment and Health Studies | 194 |
viii | 199 |
Female Infertility Effect of Perinatal Xenoestrogen Exposure on Reproductive | 202 |
Biological Monitoring of Exposure to Genotoxic Compounds Milena Černá | 210 |
Estrogen Receptor Based in vitro Assays for the Evaluation of Endocrine Disrupters | 216 |
an Evaluation of the Tradescantia | 224 |
Neurotoxic States and their Investigation Possibility for Early | 240 |
Metabolic Pathways and Individual Factors | 255 |
Pathology of Endocrine Disrupters José Jerónimo Amaral Mendes | 88 |
Molecular Changes in Thyroid Neoplasia Barbara Jarząb | 108 |
Role of BRCA1 Gene in Hereditary and Sporadic Breast Cancer | 126 |
Changes in Cellular Signaling Metabolism and Morphology | 136 |
Preneoplastic Changes in Lungs Lech Chyczewski Alicja E RydzewskaRosołowska | 147 |
P53 and P16 Alterations in Lung Cancer Jacek Niklinski Wieslawa Niklinska | 178 |
The Role of Cell Adhesion Molecules CD56NCAM in Particular in Tumor | 188 |
Fundamentals of PhysiologicallyBased Toxicokinetic Models Karen H Watanabe | 271 |
Statistical Methods for Toxicity Detection and Testing Lutz Edler | 290 |
Biologically Based Models of Carcinogenesis E Georg Luebeck | 307 |
The Cancer Risk Assessment as an Optimal Experimental Design Christos P Kitsos | 329 |
Uncertainty in Biological Modelling Werner Wosniok | 347 |
| 364 | |
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Common terms and phrases
activity allele alterations analysis animals apoptosis approach assay associated biomarkers BRCA1 breast cancer bronchial cancer risk assessment carcinogenesis carcinogens carcinoma cell cycle cell lung cell proliferation cellular chemicals chromosomal aberrations Chyczewski clonal expansion compounds concentration cytogenetic detection dioxin dose dose-response dysplasia effects endocrine disrupters environmental enzymes epidemiological epithelium estimated estrogenic evaluation experimental exposure expression extrapolation foci follicular frequency function genetic genotoxic growth factor hepatic hepatocarcinogenesis hepatocellular hormone human hyperplasia incidence increased induced involved IOS Press kinase lesions levels liver lung cancer male malignant mechanisms metabolism methods methylation molecular molecules mutations neuroendocrine cells normal observed Oncogene ovarian cancer papillary parameters pathways PBTK model PCBs phenotype physiological pollutants polymorphism population preneoplastic protein pulmonary neuroendocrine rats receptor Research response risk assessment role serum specific squamous statistical studies susceptibility thyroid cancer tissue toxicity Toxicol Toxicology tumor suppressor genes xenobiotic xenoestrogens
References to this book
Endocrine Disrupters and Carcinogenic Risk Assessment Lech Chyczewski,Jacek Niklinski,Eric Pluygers Limited preview - 2002 |
Endocrine Disrupters and Carcinogenic Risk Assessment Lech Chyczewski,Jacek Niklinski,Eric Pluygers Limited preview - 2002 |