Flow Cytometry, Immunohistochemistry, and Molecular Genetics for Hematologic NeoplasmsImmunophenotyping is the most powerful tool in the routine diagnosis of hematologic neoplasms. Immunohistochemical technique is used in histology labs for this purpose, while flow cytometry is used in clinical labs. Although separately these 2 techniques are very useful in detecting lymphomas and leukemias, the combination of both creates a very powerful and definitive diagnostic tool. The addition of molecular genetics to the book makes it an all-encompassing reference text. |
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abnormalities acute myeloid leukemia ALCL anaplastic antibodies antigens B-cell lymphoma biopsy shows blasts Bone marrow biopsy Cancer chromosome chronic lymphocytic leukemia Clin Pathol clinical clonal cytogenetic cytoplasmic demonstrated detected differential diffuse large B-cell disease DLBCL entity expression extranodal FIGURE FITC flow cytometry follicular lymphoma frequently gene rearrangement germinal center Haematopoietic and Lymphoid hairy cell leukemia Harris NL Hematol Hematoxylin and eosin histologic HLA-DR Hodgkin lymphoma IARC Press immature immunoglobulin immunohistochemistry Immunoperoxidase immunophenotype infiltration involvement karyotype large B-cell lymphoma large cell lesions Leuk leukemic lineage lymph node Lymphoid Tissues magnification malignant MALT lymphoma mantle cell lymphoma marginal zone markers megakaryocytes Molecular Genetics monoclonal monocytes morphologic mutation myeloblasts myeloma myelomonocytic negative neoplasms Oncol patients pattern peripheral blood phenotype phoma plasma cells positive present prognosis protein receptor splenic subtype Swerdlow SH syndrome T-cell thymoma tion translocation tumor cells Tumours of Haematopoietic variant