Frontiers in Celiac DiseaseAlessio Fasano, Riccardo Troncone, D. Branski Few other fields in human biology have experienced such a tremendous progress as celiac disease has during the past few years. The contributors to 'Frontiers in Celiac Disease' are world-renowned opinion leaders who made these advances possible. Their expertise has been assembled here to provide a comprehensive overview of the current knowledge of the epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of celiac disease. In addition, the stage is set for innovative strategies for preventive interventions and treatment alternatives to a gluten-free diet. A valuable reference for basic and translational scientists, this book also serves as a practical resource to healthcare professionals, including general practitioners, subspecialists, dieticians, nutritionists, and nurses and nurse practitioners. Students from different disciplines will find this book a helpful guide to expand and deepen their knowledge of celiac disease. |
Contents
Historical Perspective of Celiac Disease | 1 |
Natural History of Celiac Disease | 12 |
The Changing Clinical Presentation of Celiac Disease | 18 |
The Global Village of Celiac Disease | 23 |
HLA and NonHLA Genes in Celiac Disease | 32 |
Twins and Family Contribution to Genetics of Celiac Disease | 46 |
Biochemistry and Biological Properties of Gliadin Peptides | 57 |
Innate Immunity and Celiac Disease | 66 |
Update on the Management of Refractory Coeliac Disease | 123 |
The National Institutes of Health Consensus Conference Report | 133 |
Beyond Coeliac Disease Toxicity | 139 |
Oral Glutenase Therapy for Celiac Sprue | 148 |
Inhibitors of Intestinal Barrier Dysfunction | 157 |
Development of a Vaccine for Celiac Disease | 172 |
Regulatory T Cells in the Coeliac Intestinal Mucosa | 181 |
Strategies for Prevention of Celiac Disease | 188 |
Across the Threshold of Tolerance | 82 |
The Role of the Intestinal Barrier Function in the Pathogenesis of Celiac Disease | 89 |
Diagnosis of Coeliac Disease | 99 |
Current Guidelines for the Diagnosis and Treatment of Celiac Disease | 107 |
Current Therapy | 114 |
Towards Preventing Celiac Disease An Epidemiological Approach | 198 |
Animal Models of Celiac Disease | 210 |
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Other editions - View all
Frontiers in Celiac Disease Alessio Fasano,R. Troncone,D. Branski,W. Kiess No preview available - 2008 |
Common terms and phrases
activation adult anti-tTG antibodies antigen associated Auricchio autoantibodies autoimmune diseases barrier Basel biopsy breastfeeding CD patients celiac disease celiac patients celiac sprue cells cereals Clin clinical cytokine deamidated dermatitis herpetiformis diabetes diagnosis disorders ease effect enterocytes enteropathy epithelial epitopes exposure factors Fasano function Gastroenterol Gastroenterology genes genetic genome genotypes gliadin gliadin peptides gluten challenge gluten peptides gluten-free diet gluten-specific glutenin HLA-DQ2 IELs immune response Immunol increased induced infant inflammatory innate immune intestinal mucosa intestinal permeability intraepithelial Karger Koning F lamina propria lesion linkage lymphocytes lymphoma markers Mearin Molberg molecules Nutr paracellular pathogenesis pathway Pediatr peptides population present prolamines proteins receptor risk role Scand screening small intestinal Sollid LM specific studies symptoms syndrome T-cell T-cell response tight junction tion tissue transglutaminase toxicity transgenic mice treatment Troncone twins untreated villous atrophy vitro vivo wheat zonulin