Gastrointestinal Mucosal Repair and Experimental TherapeuticsChi-Hin Cho, Jian-Ying Wang Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C/DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field. |
Contents
Turner J R Chicago Ill Basson M D Detroit Mich | 14 |
Mucosal Repair and Ulcer Healing | 82 |
Role of Angiogenesis and Angiogenic Growth Factors in Mucosal Repair | 101 |
A Delivery System for Growth | 117 |
Helicobacter pylori Infection and Gastroduodenal Mucosal Damage | 143 |
Experimental Therapeutics | 158 |
A New Role in Gastrointestinal Protection | 180 |
Peptide and Gene Therapy with Angiogenic Growth Factors bFGF | 209 |
Gastrointestinal Protective Action of Prostaglandin E2 and EP Receptor | 227 |
| 243 | |
Other editions - View all
Gastrointestinal Mucosal Repair and Experimental Therapeutics Chi-Hin Cho,Jian-Ying Wang,C. Sakamoto No preview available - 2002 |
Common terms and phrases
acid action activity angiogenesis apoptosis bFGF Biol c-jun c-myc Ca2+ Caco-2 cells calcium cell line cell migration cell proliferation cellular chronic colitis colonic COX-2 inhibitors cytokines cytoprotection cytoskeleton damage decreased DFMO duodenal ulcers effect endogenous endothelial cells EP1 receptors epidermal growth epithelial cells epithelium ethanol experimental expression gastric epithelial cells gastric mucosa gastric ulcer gastric ulcer healing Gastroenterol Gastroenterology gastrointestinal tract gene Helicobacter pylori heparin IEC-6 cells increased indomethacin induced inflammation inflammatory inhibition iNOS integrin intestinal epithelial cells intracellular involved isoform kinase Konturek lesions lipid mechanical strain mediated membrane modulate motility mRNA mucosal mucosal injury Mucosal Repair myosin nitric oxide synthase NSAID pathway PDGF PGE2 Pharmacol Physiol platelets polyamines polysaccharides prostaglandin protective protein protooncogenes pylori infection rats regulation release response role signaling significantly small intestine stimulate stomach stress fibers studies Szabo tissue transcription vascular VEGF vitro Wang wound repair