Granulocyte Responses to Cytokines: Basic and Clinical ResearchRonald G. Coffey This volume explores the basic physiological functions of granulocytes, their modification by cytokines, and the clinical experience with cytokines - discussing the specific responses of neutrophils, eosinophils, basophils, and mast cells to individual cytokines.;Written by more than 60 experts from all over the world, Granulocyte Responses to Cytokines ...: examines the responses of granulocytes and mast cells to hormones, chemotactic peptides, and phorbol esters; details cytokine effects on morphology, micration, adhesion, phagocytosis, degranulation, and cytotoxicity against tumour cells and pathogens; covers cyclic nucleotide, protein kinases, G proteins, lipoxygenase, and leukotrienes in the regulation of granulocyte functions; indicates caution in the use of cytokine therapy for certain leukaemias due to cytokine effects on the growth of malignant cells; and presents clinical studies with granulocyte-macrophage and granulocyte colony-stimulating factors with promising results in treating genetic, virus-, and drug-induced granulocytopenias and immunodeficiencies.;Containing nearly 3900 literature citations, Granulocyte Responses to Cytokines is a guide for immunologists; hematologists; oncologists; pharmacologists; biologists, microbiologists, and biochemists; pathologists; internists; and graduate-level students in these disciplines. |
