Landmarks in Gene RegulationDavid S. Latchman Twenty years ago there was no known example in eukaryotes of a defined regulatory protein which bound to a specific DNA sequence in a target gene and regulated its expression. Since then a large number of such regulatory proteins, or transcription factors, have been defined and their roles in regulating the expression of specific genes analyzed. |
Contents
classes of messenger RNA in mouse tissues Cell 9761774 | 9 |
Regulation at transcription | 31 |
alternative | 61 |
Copyright | |
13 other sections not shown
Common terms and phrases
abundant Acad activity adult amino acid analysis assay B-globin gene base pairs Biol buffer calcitonin cDNA cell lines cell types CGRP mRNA chain containing CREB deletion deoxyribonuclease described detected differentiation digestion DNA binding DNA fragments DNA sequences DNAase DNase domain Drosophila Eco RI embryonic encoding engrailed enhancer Figure fraction fusion GAL4 gene expression genome globin heat-shocked helices helix homeodomain hsp 70 gene HSTF hybridization incubated insert interactions intervening sequences isolated kidney kinase labeled lane large-T antigen leucine levels LexA LexA-GAL4 liver molecular molecules motif mouse mRNA mutant myoblasts MyoD Natl nuclear RNA nuclei nucleotides ovalbumin ovalbumin gene oviduct peptide plasmid poly(A probe Proc promoter purified quences rabbit region regulation regulatory residues RNA polymerase RNA polymerase II sequence-specific shown specific splicing structure synthesis TATA box TFIIIA tion tissues tran transcribed transcription factor transfected transgenic tubulin upstream vitro µg/ml