Mediators of the Inflammatory ProcessPeter M. Henson, Robert C. Murphy Inflammation can be defined as a generalized, nonspecific but beneficial response of tissues to injury. The essential, protective role of inflammation can easily be seen in the life-threatening genetic diseases in which key elements of the inflammatory reaction are missing or defective. The drive to understand the underlying control processes and underlying mechanisms derives, however, more from the pathological perspective than from elucidating defense of the host to injury, and has prompted an enormous effort on the part of the pharmaceutical industry to develop efficient antagonists and inhibitors of the molecules involved in these reactions; the inflammatory mediators. This volume is intended by the authors to provide information on groups of mediators of inflammation in general, and where possible to stimulate interest and comments on the possibilities for participation of these communication molecules, mediators, in the complex but fascinating process of inflammation. |
Contents
prostanoids | 1 |
Leukotriene | 13 |
Products of 12 and 15lipoxygenase | 45 |
Copyright | |
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Common terms and phrases
Acad action activating factor activity addition antagonists appears arachidonic acid binding Biochem Biol biological Biophys blood causes Chem chemotactic Clin collagen complex concentrations cultured demonstrated effects endothelial cells enhanced enzyme eosinophils evidence expression fibroblasts formation function growth factor histamine human neutrophils IFN-y immune Immunol important increased induced infection inflammation inflammatory inflammatory cells inhibition inhibitors injury interactions interferon interleukin Invest involved isolated kinins leukocytes leukotriene levels lipoxygenase lung lymphocytes macrophages mechanism mediators membrane metabolism metabolites modulation molecules monocytes muscle Nature normal observed oxygen PAF-acether pathway peptide phospholipase plasma platelet platelet-activating factor platelet-derived growth factor polymorphonuclear potent present priming Proc production proliferation prostaglandin protein pulmonary rabbit recently receptors regulation release reported response role Science secretion shown specific stimulated structure studies substance suggest synthesis tion tissue vascular vitro vivo