Melatonin: From Molecules to Therapy

S. R. Pandi-Perumal

Nova Publishers, 2007 - Medical - 906 pages

Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a wide spectrum of research on melatonin.

Contents

• Chromatographic Analyses of Biogenic Melatonin and Its Related Indoleamines: 3
• 5Methoxylated Kynuramines Biologically Active Melatonin Metabolites and Sources of New Products: 23
• Advances on the Development of Subtype Selective Melatonin Ligands: 33
• The Interaction between Melatonin and Calmodulin A NMR and Molecular Dynamics Study: 47
• The Low Affinity Binding of Melatonin to Calmodulin Use of Computational Methods to Explain its Physiological Relevance: 69
• Neural Regulation of Melatonin Synthesis: 81
• Regulation of Melatonin Synthesis Animal versus Human Studies: 117
• Toward a Chronome Time Structure of Melatonin: 135
• Chronobiological Aspects of Melatonin Activity: 177
• The Molecular Basis to the Circadian Effects of Melatonin: 197
• Melatonin Effects on Uterine Physiology: 207
• Melatonin and Human Reproduction Why the Effect is so Elusive?: 219
• Melatonin Immunomodulatory Signal: 227
• Photoperiodic vs NonPhotoperiodic Animals Circadian and Seasonal Changes in Immunity: 247
• Melatonin An Endogenous Antiestrogen with Oncostatic Properties: 261
• Melatonin and Cancer Basic Research: 273
• Melatonin in Retinal Pathophysiology: 283
• The Physiology Pharmacology and Anatomical Distribution of Melatonin Receptors in Visual System Nuclei in the Vertebrate CNS: 295
• Antioxidant Capacity of the Neurohormone Melatonin: 317
• Protective Role of Melatonin against Mitochondrial Damage in Inflammation: 327
• Protective Effects of Melatonin against Hyperhomocysteinemia: 349
• Photo and Radiation Induced Reactions of Melatonin by Laser Photolysis and Pulse Radioloysis: 369
• Melatonin Action on Neuropeptide Induction through ReceptorMediated Mechanisms in the Brain: 387
• Melatonin Receptors in Neuroendocrine Development: 401
• The Effects of Exogenous Melatonin on the Morphology of Thyrocytes in Pinealectomized and Irradiated Rats: 413
• The Control of MT Release from Mammalian and Avian Pineal Glands: 425
• Effect of Chronic Melatonin Administration on Various Physiological Parameters from Old Wistar Rats: 457
• Section II Therapeutic Perspectives: 481
• Pineal Region Tumors: 483
• Melatonin and Cancer: 499
• Therapeutic Perspectives of Gastrointestinal Melatonin: 529
• Endogenous Versus Exogenous Effects of Melatonin: 547
• Melatonin Circadian Rhythms in Women with Depression Relationship to the Reproductive Cycle: 571
• Melatonin Therapy of Circadian Rhythm Sleep Disorders in Neurodevelopmentally Disordered Children A Neurological Viewpoint: 581
• Treatment by Melatonin of a Genetic Disorder SmithMagenis Syndrome: 605
• Melatonin and Sleep in ShiftWorkers: 615
• Role of Melatonin in the Regulation of Human Circadian Rhythms and Sleep: 633
• Ramelteon a Selective MT1MT2 Receptor Agonist Provides a Novel Treatment for Insomnia: 647
• Melatonin Dopamine and Circadian Rhythm in the Restless Legs Syndrome: 669
• Sleep and Circadian Neuroendocrine Dysregulation in Seasonal Affective Disorder: 681
• Involvement of Free Radicals and Reactive Oxygen Species in Physiological and Pathological Processes in the Thyroid Gland A Potential Role of Mel...: 699
• Role of Melatonin in Health and Diseases Headache Disorders: 717
• Ambient Illumination and Melatonin in the Natural Setting: 731
• Melatonin Effect on Smooth Muscle and Clinical Utility: 753
• Melatonin and Woman: 759
• Effects of Melatonin on the Cardiovascular System: 771
• Melatonin and Cerebrovascular Disease: 785
• Melatonin in Focal Cerebral IschaemiaEvidence for Efficacy and Priorities for Future Research: 803
• Understanding the Role of Melatonin in Epilepsy From Bench to Bedside: 813
• Role of Melatonin on Alzheimers Disease: 827
• Longitudinal Measurements of Melatonin Secretion in the Elderly Implications for Alzheimers Disease: 841
• Interactions of Melatonin with Environmental Factors: 849
• Index: 863

Bibliographic information

• Title: Melatonin: From Molecules to Therapy
• Author: S. R. Pandi-Perumal
• Editors: S. R. Pandi-Perumal, Daniel P. Cardinali
• Edition: illustrated
• Publisher: Nova Publishers, 2007
• ISBN: 1600211216, 9781600211218
• Length: 906 pages
• Subjects: Medical / Clinical Medicine; Medical / Endocrinology & Metabolism; Medical / Internal Medicine; Medical / Laboratory Medicine; Medical / Pharmacology; Medical / Physiology; Science / Life Sciences / Biology; Science / Life Sciences / Molecular Biology