Microsomes and Drug Oxidations: Proceedings of the Third International Symposium, Berlin, July 1976Volker Ullrich Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-fun ... |
Contents
BIOCHEMISTRY | 1 |
Interactions between Cytochrome P450 and NADPHCytochrome | 9 |
A Study of Cytochrome P450 Reduction by Sodium Dithionite | 17 |
Copyright | |
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acid activity added addition administration amount animals appears assay benzo(a)pyrene binding Biochem Biol Biophys buffer carbon carcinogens cell cell cultures changes Chem chromatography compared complex compounds concentration containing cultures cytochrome b5 cytochrome P-450 decrease dependent derived described determined dose drug metabolism effect electron enzyme epoxide hydratase ethanol ethylmorphine experiments female formation forms fraction function further half-life heme hepatic microsomes human hydrocarbon hydroxylase hydroxylation increase incubation indicate induced inhibition interaction isolated levels lipid liver microsomes lung male measured mechanism membrane metabolites method mg/kg mice monooxygenase NADPH nmoles observed obtained oxidase oxidation oxygen Pharmacol phenobarbital plasma possible prepared present pretreatment properties protein purified rabbit reaction reduced reductase REFERENCES reported shown shows similar specific spectral spectrum studies substrate suggest Table tion tissues treated treatment University values various vitro vivo