Molecular Aspects of the Stress Response: Chaperones, Membranes and NetworksPeter Csermely, László Vígh We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes. The volume starts with an introduction to the concept of molecular chaperones in their original sense: R. John Ellis, the founder of the chaperone concept describes chaperones as mediators of correct assembly and/or misassembly of other macromolecular complexes. This sets the tone of the book, where later chapters give detailed examples of the richness of chaperone ac tion by hundreds of other proteins and membrane structures. The reader will learn the role of chaperone classes such as Hsp27 or Hsp90, the action of highly organized chaperone networks in various cellular compartments such as the ER or mitochondrial/ER networks as well as the molecular details of the signaling mechanisms leading to chaperone induction during stress. Various special stress defense mechanisms against oxidative stress or dryness will also be covered. Membranes comprise a surprising mixture of stability and dynamics in the cell. Their role in the regulation of the stress response has been accepted only slowly in the field. Two chapters summarize this important aspect of the stress response showing the importance of membrane hyperstructures, lipid species composition, protein/ membrane interactions and cold adaptation. |
Other editions - View all
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks Peter Csermely,László Vígh No preview available - 2006 |
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks Peter Csermely,László Vígh No preview available - 2010 |
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Acad Sci USA animals apoptosis apoptotic binding Biochem Biol Chem biological Biophys Ca² Ca2+ Caenorhabditis elegans calnexin cancer caspases cell death cellular chains complex cytoplasmic cytosol degradation denatured desaturase disease domain Drosophila effects elegans EMBO endoplasmic reticulum expression function gene genetic heat shock factor heat shock protein heat shock response heat shock transcription HSF1 activity HSP90-containing Hsps human induced inhibition interactions interactors mechanism mediated membrane lipid misassembly misfolded proteins mitochondrial modules Mol Cell Biol molecular chaperones molecules mutations Natl Acad Sci neurons oligomerization organelle oxidative stress phenotype phosphorylation Physiol polypeptide polyQ proteins Proc Natl Acad proteasome protein aggregation protein folding protein kinase receptor refolding role shock transcription factor signal transduction signaling pathways soluble specific Springer Science+Business Media stability stress proteins stress response structure studies substrate sucrose target temperature tion toxic transcription factor transcriptional activity translocation trehalose trimeric unfolded yeast
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Page ii - Editorial Board: NATHAN BACK. State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY. Wistar Institute ABEL LAJTHA, NS Kline Institute for Psychiatric Research RODOLFO PAOLETTI.