Molecular and Cellular Mechanisms of ToxicityWritten by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology. |
Contents
| 3 | |
| 19 | |
| 35 | |
| 69 | |
| 85 | |
| 101 | |
| 125 | |
| 147 | |
Genetic Variation in Human and Laboratory Animal Populations and Its Implications for Toxicological Research and Human Risk Assessment | 165 |
| 185 | |
| 207 | |
| 219 | |
Other editions - View all
Molecular and Cellular Mechanisms of Toxicity Lewis L. Smith,Francesco De Matteis Limited preview - 2019 |
Molecular and Cellular Mechanisms of Toxicity Lewis L. Smith,Francesco De Matteis Limited preview - 2019 |
Common terms and phrases
32P-postlabeling Acad active cell death aflatoxin agents Aldridge alkylating animals antioxidant apoptosis apoptotic asbestos ascorbic acid benzo(a)pyrene Biochem Biol biological biomonitoring Biophys Bursch Ca2+ Cancer Res carcinogenesis carcinogens cellular Chem chemical chrysotile compounds cysteine damage detection disease DNA adducts dose effects enzyme esterase experimental exposure Festing fibers fluorescence formation gene genetic glutathione glutathione peroxidase hemoglobin hepatocellular carcinoma hepatocytes human inbred strains increase induced inhalation inhibition inhibitors interaction internucleosomal involved labeled laboratory levels lipid peroxidation lung mammary mechanism membrane mesothelioma metabolism metabolites methylating mice mitochondrial molecular mRNA mutation Natl nervous system neurons neuropathy neurotoxicity normal nuclear nucleic acids oncogene OPIDP oxidative stress oxygen pathway permeability transition peroxidase Pharmacol probes Proc procarbazine protein pyrethroids rat liver reaction reactive redox cycle Reed samples Schulte-Hermann sensitivity species spectrometry studies tamoxifen target thymocytes tissue toxicity Toxicol Toxicology transferase tumors vitamin vitamin E vivo xenobiotics