Molecular Aspects of Human DiseaseJohn W. Gorrod, Ottavio Albano, Sergio Papa |
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acid action potential activity adenylate cyclase adrenergic receptors agents alkylating amino azaheterocycles antigen antiviral artery Biochem Biol Biophys bleomycin blood Bordetella pertussis Bordetella pertussis adenylate Br-daunomycin Ca2+ calcium calmodulin carcinogenic cardiolipin catecholamines cell lines cellular channels Chem chemical cholecystokinin chronic clinical clones complex compounds concentration covalent binding cystamine cytochrome cytosolic cytotoxic decrease diagnostic disease drug effects EGF-r enzyme fractions function gallbladder gallstone gene glutathione Gorrod hepatic hepatocytes hepatotoxicity hormone human hypertensive increase incubated induced inhibition inhibitors insulin interaction intracellular isolated ketanserin lesions leukaemia levels lymphocytes mammalian mechanisms menadione metabolism metabolite Methisoprinol mitochondria molecular mutagenic N-oxidation NHâ‚‚ normal oncogenes oxidation patients pertussis adenylate cyclase Pharmacol Pharmacology phosphorylation plasma membrane platelets polypeptides Portincasa protein purified rat liver reaction reactive intermediates reductase REF52 cells response role serotonin smooth muscle sodium specific studies synthesis thiol tissue toxicity tumours vascular virus vitro vivo