Neurobiology of DiseaseAlan L. Pearlman, Robert C. Collins The study of the mechanisms by which diseases alter the function of the nervous system was once well described as "Neurological Pathophysiology," the title of previous editions of this book. But when disciplines as diverse as molecular genetics and radiation biophysics converge on the analysis of the nervous system and its disorders, a title with broader meaning is required to encompass them. The change in the book's title reflects a change in its scope, as it includes much more information on functional and anatomical systems than the early editions. New to this fourth edition are three chapters on Memory, Genetic Disorders, and Brain Tumors. Infections are given more extensive treatment, the original chapter being divided into two, the first on bacteria, fungi and parasites, the second on viruses. All other chapters have been updated. For medical students and physicians the text offers and introduction to the scientific basis of clinical neurology--the framework on which diagnosis and treatment are based. For graduate students and scientists in the field of neurobiology, it describes the expression of fundamental mechanisms gone awry, and provides clues for elucidating those mechanisms. |
Contents
Normal and Demyelinated Axons | 3 |
Peripheral Nerve | 22 |
Neuromuscular Junction | 44 |
Copyright | |
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abnormal acetylcholine acid action potential activity afferent anatomical artery associated auditory axon basal basal ganglia behavior bilateral blood blood-brain barrier brainstem cause cellular cerebellar cerebellum cerebral cerebral cortex changes clinical CNS infection conduction cortex cortical cranial damage decrease deficits dementia demyelinated disease disorders dopamine dorsal dysfunction effect encephalopathy excitatory extracellular factors fibers fluid focal frontal function gene globus pallidus glucose HD gene human Huntington's disease hypothalamus impaired increased infarction input intracranial involved ischemia lateral lesions loss mechanisms medial membrane memory meningitis ment metabolic motor neurons movements multiple sclerosis muscle myasthenia gravis myelin nerve nervous system neurological normal nucleus occur onset optic pain pathways patients peripheral posterior primary produce protein receptors reflex region response result Schwann cell seizures sensitive sensory spinal cord stimulation studies symptoms synaptic syndrome temporal lobe thalamus tients tion tissue tumor vascular vestibular viral virus viruses visual