Proceedings, Volume 21

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Page 8 - ... erythema and hemorrhagic edema in the subcutaneous tissue overlying the muscle. The skin reaction to heat-killed pneumococci was negative in most of these animals, and when positive was of a suppurative type, marked by less edema and more leukocytosis. Control animals gave uniformly negative results. Among human adult cases of lobar pneumonia the reaction (which was characterized by a local edema and erythema) was elicited as early as the fifth and as late as the thirteenth day of the disease...
Page 28 - Part of a dissertation presented by the writer for the degree of Doctor of Philosophy, University of Pennsylvania, 1918.
Page 24 - J to 1 per cent, concentration. 3. The addition of a moderate excess of alkali beyond the amount required for neutralization does not increase the toxicity, as determinable by the duration of life of the experimental animal. It is possible, however, that it may have other untoward effects. 4. The...
Page 9 - The reaction is regarded as similar to the tuberculin reaction and is indicative of a state of allergy to pneumotoxin. Sensitization to the toxin presumably takes place with its liberation (by the action of normal body enzymes upon pneumococci normally localized in the lung alveoli) at the time of the prolonged chilling due to exposure. Failure to elicit the reaction during convalescence...

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