Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDSEric Wickstrom A wide range of new technology involving a direct genetic approach to the treatment of disease using nucleic acid therapeutics is the main focus of this absorbing book. Provides in-depth coverage of the rapid progress of this new technology, from its theoretical stage to its current position at the verge of experimental applications, along with provocative discussions of the therapeutic implications. |
Contents
ONCOGENES | 7 |
Dissections and reconstructions | 20 |
Targeting and Intracellular Delivery of Antisense Oligonucleotides | 25 |
Copyright | |
25 other sections not shown
Common terms and phrases
Acad Agrawal alkylating anti antigen antisense c-myc antisense fos antisense oligomers antisense RNA antisense RNA expression apoptosis AS-Fos assay binding Biol c-fos c-fos expression c-jun c-myb c-myc c-myc gene c-myc mRNA Cancer carcinoma cell cycle cell line cells treated cellular cleotides clones codon complementary complex concentration CRBP culture differentiation dose duplex effect formation Fos and Jun function gene expression gonucleotides growth factor helical HL-60 cells human incubated induced infection inhibition inhibitory Jurkat leukemia levels methylphosphonate mg/kg monocytic mouse mRNA Natl Nature London normal nuclear nucleic acids nucleotide oligodeoxynucleotides oligodeoxyribonucleotides oligomers oligonu oligoribonucleotides oncogene p2as PDGF PDGF-A phosphorothioate plasmid platelet-derived growth factor Proc promoter protooncogene reagents receptor regulation replication retinoic acid retinoid retinoid receptors sequence sequence-specific serum specific synthesis target tion tisense TNF-a trans transcription transfected transformed treatment triple helix tumor uptake viral virus vitro Wickstrom Zarytova