QSAR: Quantitative Structure-activity Relationships in Drug Design : Proceedings of the 7th European Symposium on QSAR, Held in Interlaken, Switzerland, 5-9 September 1988Jean-Luc Fauchère |
Contents
QSAR Methods and Stereoselectivity in Action | 3 |
Consequences of the Hansch Paradigm Part II | 15 |
Albert J Leo Pomona College C S May Pharmaceutical Products | 22 |
Copyright | |
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Common terms and phrases
affinity agonists Alan amino acids analogs analysis antagonists application approach Ariëns atom attractor binding Biochem biological activity calculated carbon chain Chem cluster complex compounds computational chemistry conformation correlation crystal structures cyclodextrin data set database derived descriptors determined DHFR dihydrofolate reductase Drug Design effect electronic electrostatic potential enantiomers energy enzyme equation experimental Figure fragments functional groups geometry graphics Hansch Hopfinger hydrogen bond hydrophobic inhibition inhibitors interactions Kier ligand lipophilicity Liss log 1/C log P values logP measured method molecular modeling molecular shape molecules multivariate octanol optimization parameters partition coefficients peptide Pharmacol pharmacological pharmacophore phase piperidine PP.s predicted properties protein QSAR QSAR studies Quantitative Structure-Activity Relationships reaction receptor REFERENCES regression Relationships in Drug Research SARSS selection similarity solute solvent statistical steric substituent constants substituents substructure superatoms Table techniques Testa tion topology toxicity trypsin variables Waterbeemd Wipke