Recent Advances in IgA NephropathyIgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases. |
Contents
Discovery of a Distinct Glomerular Disorder Keng Thye Woo Richard J Glassock and Kar Neng Lai | 1 |
2 Epidemiology and Ancestral Difference Francesco P Schena and Francesco Pesce | 9 |
3 Genetic Contribution to IgA Nephropathy Patrick H Maxwell and Yiming Wang | 21 |
4 Histopathology Immunofluorescence and Ultrastructural Examination Fernand M Lai | 37 |
5 Tubulointerstitial Injury in IgA Nephropathy Joris J Roelofs and Sandrine Florquin | 55 |
6 Podocyte Pathology Kar Neng Lai and Joseph C K Leung | 69 |
7 Clinicopathologic Findings Bruce A Julian and Robert J Wyatt | 83 |
8 Clinical Course of Primary IgA NephropathyFrancois C Berthoux and Hesham Mohey | 107 |
16 AntigenDependent Mechanism of IgA Nephropathy Yasuhiko Tomino and Yoshio Shimizu | 225 |
17 Complement Activation Sydney C W Tang and Kar Neng Lai | 237 |
18 Cytokines and Growth Factors Jürgen Floege and Tammo Ostendorf | 243 |
19 Monocytes and Macrophages Yohei Ikezumi and David J NikolicPaterson | 267 |
20 ReninAngiotensin System Kar Neng Lai and Joseph C K Leung | 289 |
21 Corticosteroids Claudio Pozzi and Lucia Del Vecchio | 309 |
ReninAngiotensin Blockade Rosanna Coppo and Licia Peruzzi | 321 |
23 Other Immunomodulatory Agents Sydney C W Tang and Kar Neng Lai | 339 |
9 Special Clinical Syndromes Judit Nagy and Tibor Kovács | 121 |
10 IgA Nephropathy in Children Ronald J Hogg | 139 |
11 Recurrent IgA Nephropathy in Transplant Bo Ying Choy and Kar Neng Lai | 149 |
12 IgA Molecule JanWillem Eijgenraam Mahamed R Daha and Cees van Kooten | 161 |
13 IgA ImmuneComplex Jan Novak and Jiri Mestecky | 177 |
14 B and T Lymphocytes Abdalla Rifai and Ann Chen | 193 |
15 IgA Receptors and Mesangial IgA Deposition Ivan C Moura and Renato C Monteiro | 211 |
Other editions - View all
Common terms and phrases
ACEi activation angiotensin antibodies antigens apoptosis associated ATR1 ATR2 binding biopsy chronic Clin Nephrol clinical coeliac disease correlated creatinine crescentic cytokines effect expression fibrosis g/day galactose-deficient gene genetic glomeru glomerular glomeruli glomerulonephritis glomerulosclerosis glucocorticoids glycosylation growth factor hematuria Henoch-Schönlein purpura histological hypertension IgA immune IgA nephritis IgA nephropa IgA nephropathy IgA production IgA1 IgAN patients immune complexes immune response immunoglobulin immunoglobulin A nephropathy Immunol increased induce inflammatory inhibitors injury interstitial Kidney Int lesions macrophages markers matrix mediated mesangial cells mesangial IgA deposition mesangium mice mizoribine molecules monocyte mucosal nephritis Nephrol 18 Nephrol Dial Transplant Nephrology pathogenesis Pathol patients with IgA PDGF Pediatr pIgA podocytes polymorphism primary IgA nephropathy prognosis protein proteinuria receptor recurrent renal biopsy renal disease renal failure renal function renal survival renin-angiotensin system role serum IgA Soc Nephrol steroid pulse therapy studies Suzuki TGF-ẞ tion tissue tonsillectomy transforming growth treatment tubulointerstitial urinary