Secretory Systems and ToxinsMichal Linial, Alfonso Grasso, Phillip Lazarovici This volume deals with the relationships between toxins and one of the most fundamental processes in any living cell - the secretory cycle. The reader will find up-to-date information on secretion, generated by experts in this fast evolving field. In the last decade extensive molecular and cellular studies have exposed the molecular similarity among most known secretory systems. In this book secretion is discussed from its basic mode found in yeast up to its most sophisticated version in neurotransmitter release in nerve terminals. A comprehensive view on the mode of action of toxins which block secretion but also those which cause hyper-activation of exocytosis is provided. This book addresses the issue of toxin action by deciphering the molecular and cellular basis of exocytosis in various organisms and cellular contents. |
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Secretory Systems and Toxins Michal Linial,Alfonso Grasso,Phillip Lazarovici No preview available - 1998 |
Common terms and phrases
Acad acid action activity addition affinity antibodies appears associated binding Biochem Biol block botulinum neurotoxin brain Ca2+ calcium calcium channels cells channels Chem chromaffin cells complex components concentration containing culture cytoplasmic dependent distinct docking domain effect essential et al evidence exocytosis expression Figure formation function fusion gangliosides gene granules identified increase indicating induced inhibition interaction intracellular involved Jahn kinase light lipid localization mechanism mediated membrane protein molecular molecule Montecucco mutants myosin Nature nerve terminals neurexin neurons Neurosci neurotoxins neurotransmitter release observed pathway phosphorylation plasma membrane pore potential present presynaptic Proc properties protein receptor region regulated responsible role Scheller Schiavo secretion secretory sequence shown shows signal similar SNARE specific spider step stimulation structure studies Südhof suggesting synapsin synaptic vesicle synaptobrevin synaptophysin synaptosomes synaptotagmin syntaxin TeNT tetanus toxin transmitter release transport VAMP venom yeast