Seizures and Epilepsy in the ElderlyEpileptic seizures in the elderly population occur more frequently that previously thought. Recent epidemiologic data indicate that the incidence of seizures rises sharply after middle age. Seizures occur because of previous stroke or head trauma in addition to a variety of systemic derangements, drugs, drug withdrawal, or acute intracranial disease. The aging process creates particular problems in diagnosis, specific therapy, and long-term management. Prompt diagnosis and therapy are essential. This bookemphasizes the physiologic and pathologic changes associated with aging that have an impact on diagnosis and treatment. It will include epidemiology, clinical diagnosis, imaging and electrophysiologic studies, age-related physiologic changes, pharmacokinetics, drug interactions, current and new antiepileptic drugs, and management. |
Contents
Epidemiology of Seizures and Epilepsy in the Elderly | 7 |
Epileptogenesis and the Aging Brain | 21 |
Endocrinologic Changes in the Elderly Predisposing | 45 |
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Common terms and phrases
abnormalities acid activity acute symptomatic seizures adults adverse AEMs age group age-related alpha rhythm altered Alzheimer's disease anticonvulsant antiepileptic drugs antiepileptic medications approximately assessment associated benzodiazepines blood brain carbamazepine cause cerebral changes clearance Clin Pharmacol clinical cognitive concentrations decrease dementia diagnosis disorders dose efficacy elderly individuals elderly patients elderly subjects Electroencephalogr electroencephalogram epileptic seizures epileptiform etiology evaluation felbamate focal function GABA Gabapentin genetic Geriatr glucose Hauser hemorrhage hepatic hypoglycemia hyponatremia imaging impaired incidence increased infarction insulin interactions lamotrigine lesions levels mechanisms metabolism metabolites monotherapy mortality myoclonus Neurol Neurology normal occur older than age onset oxcarbazepine partial seizures patients with epilepsy pattern pharmacokinetics phenobarbital phenytoin plasma population protein binding receptors reduced renal response result risk factors seizure types serum significant status epilepticus stroke temporal therapeutic therapy Tiagabine tion tonic-clonic Topiramate toxicity treatment tumors unprovoked seizures valproate vascular vasopressin vigabatrin younger