Targeting of Drugs With Synthetic SystemsGregory Gregoriadis, Judith Senior, George Poste Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharmacological action were discussed in the two previous NATO Advanced Studies Institutes (ASI) of this series, "Targeting of Drugs" and "Receptor-Mediated Targeting of Drugs", the proceedings of wh ich were published by Plenum in 1982 and 1984 respectively. This book contains the proceedings of the 3rd NATO ASI "Targeting of Drugs with Synthetic Systems" held as be fore at Cape Sounion, Greece during 24 June-5 July 1985. It deals mostly with man-made carriers such as a variety of polymers, matrices, liposomes and other colloidal micro particles. The twenty chapters discuss the interaction of such carriers with the biological milieu, approaches to bypass the reticuloendothelial system (or, when needed, take advantage of its interception of carriers to optimally deliver drugs to phagocytes) and ways to improve delivery to specific cells, often with the help of carrier-linked ligands. |
Contents
Mannose Binding Proteins in the Liver and Blood | 1 |
Their Role | 13 |
Possible Targets | 25 |
Copyright | |
15 other sections not shown
Other editions - View all
Targeting of Drugs With Synthetic Systems Gregory Gregoriadis,Judith Senior,George Poste Limited preview - 2013 |
Targeting of Drugs With Synthetic Systems Gregory Gregoriadis,Judith Senior,George Poste No preview available - 2012 |
Common terms and phrases
acid activity adsorption agents alprenolol amino antigen aqueous bilayer binding Biochem Biol biological Biophys blood Cancer carbohydrate cell membrane cell surface cellular Chem CHOL cholesterol clearance coated colloidal compounds concentration conjugate D-lys degradation delivery dextran distribution dose drug carriers effect endocytosis endosome endothelial cells enzymes function glycolipids glycoproteins Gregoriadis heparin hepatic hormone hydrophobic increase inhibition inhibitors injected interaction interferon intracellular intravenously Kupffer cells L-ADM L-AmpB ligand lipid liposome-encapsulated liposomes liver lysosomal macromolecules macrophages mannose receptor metabolism mice microspheres molecular molecules monoclonal antibodies mouse MTX-poly nanoparticles Natl parenchymal cells particles peptidase peptides phagocytosis Pharm pharmacophores phase phospholipid pinocytosis plasma poloxamer poly Lys polymer polymeric polystyrene potential proteins radioactivity release retention serum Shen and Ryser sinusoidal cells spacer specific spleen structure studies Table targeting therapeutic tissue transport treatment tumor cells uptake vesicles vitro vivo