The Biogenesis of Cellular OrganellesThe Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.
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Contents
Theory of Organelle Biogenesis A Historical Perspective | 1 |
The History of Organelle Recognition | 2 |
Protein Synthesis and Targeting | 4 |
Organization into Complex Structures | 10 |
Organelle Inheritance | 11 |
Challenges | 13 |
Protein Coats As Mediators of Intracellular Sorting and Organelle Biogenesis | 19 |
A Scaffold for Protein Coats | 22 |
Golgi Function and Compartmentalization | 99 |
Transport within the Golgi Complex | 101 |
Interphase | 102 |
Mitosis | 104 |
Lysosome Biogenesis and Dynamics | 111 |
Models for Lysosome Biogenesis | 112 |
Synthesis and Delivery of Lysosomal Hydrolases | 113 |
Synthesis and Trafficking of Lysosomal Membrane Proteins | 114 |
Adaptors for Coats of the LateSecretory and Endocytic Pathways | 25 |
Protein Coats of the Early Secretory Pathway | 29 |
AdaptorRelated Proteins Define Novel Coats of the Secretory and Endocytic Pathways | 32 |
The Role of Proteins and Lipids in Organelle Biogenesis in the Secretory Pathway | 45 |
Protein Sorting Confers a Transient Nature to Secretory Pathway Organelles | 46 |
Fission and Fusion | 50 |
Exit Mechanisms in Trafficking | 52 |
Tethering Priming and Fusion | 55 |
Endoplasmic Reticulum Biogenesis Proliferation and Differentiation | 63 |
ER Functions | 65 |
Building Blocks of the ER | 69 |
ER Biogenesis | 73 |
ER Network Formation | 74 |
ER Subdomains | 80 |
ER Differentiation | 81 |
Putting It All Together | 84 |
Appendices | 85 |
The Golgi Apparatus Structure Function and Cellular Dynamics | 96 |
Lysosomes and Endosomes Undergo Fusion and Fission | 115 |
Lysosomes Are Capable of Fusion with the Plasma Membrane | 117 |
Movement of Lysosomes | 118 |
Nucleogenesis | 127 |
The Nuclear Envelope in Mitosis | 128 |
PostMitotic Biogenesis of the Nucleolus | 132 |
Mitochondrial Biogenesis | 138 |
Mitochondrial Dynamics | 139 |
Mitochondrial Protein Import | 142 |
Mitochondrial Protein Export | 150 |
Metal Ion Transport | 152 |
The Biogenesis and Cell Biology of Peroxisomes in Human Health and Disease | 164 |
Biogenesis of Peroxisomal Membranes | 166 |
Early Acting Peroxins Pex3p | 168 |
A Precursor Organelle to the Peroxisome? | 169 |
Molecular Mechanisms of Peroxisomal Protein Import | 170 |
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Acad Sci USA actin adaptor AP complexes ARF1 associated binding Biochem biogenesis Biol Chem brane calcium cargo Cell Biol 1998 Cell Biol 2001 Cell Sci cellular cisternae clathrin compartments components COPII cytoplasmic cytoskeleton cytosolic domain dynamics effector EMBO endocytic pathway endocytosis endoplasmic reticulum enzymes eukaryotic exit factors fission formation function gene genetic Golgi apparatus Golgi complex Golgi membranes GTPase inner membrane interactions intermembrane space intracellular late endosomes lipid lumen lysosomes mammalian cells mannose 6-phosphate receptors matrix mechanisms mediated membrane fusion membrane proteins microtubules mitochondrial mitosis Mol Biol Cell molecular molecules motifs mutants Natl Acad Sci nuclear envelope nuclear envelope assembly organelles outer membrane overexpression peroxisomal plasma membrane Proc Natl Acad protease protein coats protein import receptor recruitment recycling regulated role Saccharomyces cerevisiae secretory pathway signals SNARE proteins sorting specific structure studies subunits syntaxin synthesis targeting translocation transport tubules vesicles vesicular vitro yeast