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acid activity adducts alcohol analysis animals aquatic assay assessment binding BIOCHEM Biol blood brain cadmium calcium cancer carcinogenic cells Cent Chem chemical CHEMOSPHERE Chlorinated chromosome chronic cocaine coll compounds concentrations culture cytochrome cytochrome P450 cytotoxicity decreased detected Dioxins dopamine dose drug En;en endotoxin ENVIRON Environmental Toxicology enzymes ethanol evaluated excretion exposed ﬁrst ﬁsh Health hepatic hepatocytes Hosp human increased induced inhibition injection inst investigated irradiation kidney levels lipid liver lung lymphocytes macrophages male metabolism metabolites mg/kg mice mutagenic MUTAT Natl neurons observed occupational exposure organic OSAR in Environmental oxide P.O. Box patients pesticides PHARMACOL plasma pollution potential present produced protein QSAR rabbits radiation rats receptors renal response risk samples serum signiﬁcant signiﬁcantly smoking speciﬁc TCDD tion tissue TOXICOL toxin treatment tumors Univ Unlv uptake venom vitro