Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management (Google eBook)

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Springer Science & Business Media, Oct 28, 2007 - Medical - 376 pages
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A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as 'endothelial and leukocyte microparticles' and 'gene microarray technology' to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
  

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Contents

Endothelial CellLeukocyte Interactions During CNS Inflammation
1
Multiple Sclerosis A Disease of Miscommunication Between the Immune and Central Nervous Systems?
17
Cytokines and Brain Health and Disease
41
Chemokines and Central Nervous System Disorders
81
Circulating CellDerived Microparticles in Thrombotic and Inflammatory Disorders
91
Multiple Sclerosis Clinical Features Immunopathogenesis and Clinical Management
103
Neuroprotective Effects of Interferonβ in Multiple Sclerosis
133
Acute Disseminated Encephalomyelitis
147
Transverse Myelitis Clinical Manifestations Pathogenesis and Management
217
Optic Neuritis Pathogenesis Immunology Diagnosis and Clinical Management
237
Central Nervous System Vasculitis Pathogenesis Immunology and Clinical Management
257
Neurosarcoidosis Pathogenesis Immunology and Clinical Management
269
Neuropsychiatric SLE Pathogenesis Immunology and Clinical Management
291
Gene Expression in HIVAssociated Dementia
305
Human TLymphotropic VirusAssociated Neurological Disorders Pathogenesis Immunology and Clinical Management
319
West Nile Virus Infection of the Nervous System Pathogenesis Immunology and Clinical Management
337

Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis
163
Neuromyelitis Optica
203

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