Bile Acids as Therapeutic Agents: From Basic Science to Clinical PracticeG. Paumgartner, A. Stiehl, W. Gerok |
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P J Meier | 13 |
purification cloning | 29 |
Molecular basis of regulation of cholesterol 7xhydroxylase | 45 |
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absorption activity administration animals bile acid synthesis bile salts bilirubin Biochem Biol calcium carbonate CDCA cells changes Chem chenodeoxycholic acid cholestasis cholestatic cholesterol 7a-hydroxylase cholic acid chromatography chronic Clin clinical compared compound concentrations conjugates containing decreased determined dissolution effect enzyme excretion experiments expression Figure formation fraction function gallbladder gallstone Gastroenterology glucuronides hepatic hepatocytes Hepatology human hydrophobic hydroxyl improvement increased indicate induced infusion intestinal isolated labelled levels Lipid Res liver disease major mass mean measured mechanism membrane metabolism method microsomes mRNA normal observed obtained pathway patients plasma pool present primary biliary cirrhosis properties protein rat liver ratio recently recurrence reduced reductase regulation reported secretion serum showed shown significant significantly specific steroid stones structure subjects substrate suggest Table taurocholate tests therapy transport treatment TUDC UDCA ursodeoxycholic acid values vesicles