Molecular Basis and Thermodynamics of Bioelectrogenesis
Springer Science & Business Media, Oct 31, 1990 - Medical - 181 pages
Despite the fact that many years have elapsed since the first microcalorimetric measurements of an action potential were made, there is still among the research workers involved in the study of bioelectrogenesis a complete overlooking of the most fundamental principle governing any biological phenomenon at the molecular scale of dimension. This is surprising, the more so that the techniques of molecular biology are applied to characterize the proteins forming the ionic conducting sites in living membranes. For reasons that are still obscure to us the molecular aspects of bioelectrogenesis are completely out of the scope of the dynamic aspects of biochemistry. Even if it is sometimes recognized that an action potential is a free energy-consuming, entropy-producing process, the next question that should reasonably arise is never taken into consideration. There is indeed a complete evasion of the problem of biochemical energy coupling thus reducing the bioelectrogenesis to only physical interactions of membrane proteins with the electric field: the inbuilt postulate is that no molecular transformations, in the chemical sense, could be involved.
What people are saying - Write a review
We haven't found any reviews in the usual places.
acetylcholine action potential amino acids amplitude axonal membrane axoplasm bilayer biochemical bioelectrogenesis Biol biological biological membranes Biophys brain capacitive cell membranes changes charge chemical transmitter compartments concentration conducting sites constant cytoplasm decrease depolarization dissipation electric organ electric potential electrochemical equilibrium potential electrochemical gradients electrode electrotonic entropy enzyme equation excitable cells excitable membranes external flux free energy function glucose glutamate glycogen glycolysis heat of activity Hodgkin hydrophobic increase initial heat ionic ionic channels ionic currents ionic flows ionic pumps ions Krebs cycle lipid Margineanu membrane potential membrane proteins metabolism mitochondrial molecular molecules muscle nerve fibres nerve impulse neural neurons parameters pentose permeability Physiol plasma membrane post-synaptic membrane potassium potential difference processes produced propagation properties Ranvier node receptor resting potential Schoffeniels signals sodium channels solution specific squid giant axon stimulation structure synaptic synthesis thermodynamics thiamine ThTP tissues transition transmembrane potential transmission transport variation vesicles