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1,25-dihydroxyvitamin 25-hydroxyvitamin abnormal age-related aluminum biochemical biopsy bisphosphonates Bone and Mineral bone density bone formation bone loss bone mass bone mineral bone remodeling bone resorption bone turnover bone volume calcification calcitonin calcitriol calcium calcium absorption calcium intake cells changes Clin clinical collagen correlation cortical bone decrease defect deficiency dietary disorder doses effects estrogen evidence excretion factors femoral neck fluoride function gene genetic growth hip fracture histomorphometry hypercalcemia hypercalciuria hypophosphatasla hypophosphatemia iliac increased bone kidney lesions levels malignancy marrow measured mechanism menopause microdamage mutations normal occur osteoclasts osteoid osteomalacia osteoporosis Paget's disease parathyroid hormone Parfitt pathogenesis patients phosphate phosphorus plasma postmenopausal present primary hyperparathyroidism protein pseudohypoparathyroidism reabsorption receptor reduced renal tubular response rickets risk serum calcium serum concentration skeletal skeleton spine stimulation studies suggest surface syndrome therapy tissue trabecular bone treatment tumor urinary values vertebral vitamin women