HIV molecular organization, pathogenicity and treatment
John Morrow, Nancy L. Haigwood
Elsevier, 1993 - Medical - 386 pages
It is now 12 years since the first reports of AIDS, and the disease has become a pandemic of devastating proportions. Despite the enormous social, emotional and economic costs, some rays of hope are now visible. Biomedical research into the problems presented by the disease has gained considerable momentum. The discovery of the etiologic agent, the human immunodeficiency virus (HIV), in the mid-1980's has resulted in massive efforts to characterize the organism. In addition the development of new therapies is under intense study and anti-viral and immunomodulating drugs are showing some efficiency in preliminary testing. To date, attempts to produce a protective vaccine have been only partially successful, but these investigations are continuing unabated and we can remain cautiously optimistic that these tremendous efforts may yield some promise in the medium, if not short-term, period. In compiling this volume, the authors have aimed to review key topics in the fast-moving field of HIV research and provide the reader with easy access to current literature and trends in experimentation.
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HIV Molecular Organization Pathogenicity and Treatment
Clinical manifestations of AIDS
Prevention of opportunistic infections
11 other sections not shown
Acad activity AIDS Res amino acids animals antigen apoptosis asymptomatic CD4 binding CD4+ cells CD8+ cell lines cellular chimpanzees Clercq clinical clones complex cytotoxic disease domain encoded envelope glycoprotein epitopes expression function fusion genetic genome glycoprotein Hirsch HIV and SIV HIV infection human immunodeficiency virus immune responses immunodeficiency virus type Immunol infected cells inhibit inhibitors interaction lentiviruses Luciw lymphocytes macaques macrophages mangabeys membrane molecular molecules monoclonal antibodies mRNA mutations Natl neutralizing antibodies NF-kB pathogenesis patients PBMC peptides polyprotein primate lentiviruses Proc protease protein receptor recombinant region retroviral Retroviruses reverse transcriptase role sCD4 Science sequence simian immunodeficiency virus Sodroski soluble CD4 sooty mangabeys specific structure studies subunit syndrome T-cell target tion transactivation transcription transmission tropism V3 loop vaccine viral RNA virions Virol Virology virus infection viruses vitro vivo Wong-Staal