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activity adhesin agent of paracoccidioidomycosis analysis analyzed antibodies antifungal antigen armadillos assays Botucatu Brazil capsulatum catalase cDNA Cell Biology cell wall characterized Ciencias clinical clones CNPq Conclusion conidia culture cytokines Departamento Dermatologia detected diagnosis differentiation dimorphic fungus disease ELISA encoding endemic evaluated experimental expression extracellular Faculdade de Medicina FAPESP Financial support fungal fungi fungus genes genome granulomas histoplasmosis host human IFN-y immune response Imunologia inhibition Instituto Adolfo Lutz interaction Introduction and Objectives isolates itraconazole Latin America lesions levels lungs lymphocytes mAbs macrophages Methods and Results mice Molecular Biology molecules monocytes mycelial mycelium mycosis observed Paracoccidioides brasiliensis paracoccidioidomycosis PCM pathogenic Pbl8 peptides Pereira phagocytosis present production protein pulmonary recombinant role samples Sdo Paulo sequence serum showed Silva Southern blot specific systemic mycosis TNF-a transcriptome transcripts transition treatment UNESP Universidade Federal virulence vitro yeast yeast cells yeast form yeast phase