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Accumulation and Release From Storage Depots
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absorbed absorption activity adsorption agents albumin aluminum animals antibody antigen aureus Autian bacteria beryllium biocompatibility biological biomaterials Biomed blood bone cadmium Cancer carcinogenesis carcinogenic cells cellular ceramics chapter chemical chromium chronic Clin clinical cobalt components compounds concentration culture degradation dental devices dialysis drugs effects enzymes excretion experimental factors fibrinogen Figure foreign body granuloma human hydrophobic immune response implant materials induce infection inflammatory inhibition interactions interfacial intestinal involved ions layer levels liver lung lymphocytes macrophages mechanisms membrane metabolic metal molecules mutagens neoplasm nickel occur Oppenheimer organic orthopedic oxide particles patients phagocytosis phosphatase physiological plasma plastic polyethylene polyglycolic acid polymeric polymers polymorphonuclear leucocytes polyvinyl polyvinyl chloride present produced prostheses proteins rats release route Sample sarcomas sensitivity serum soft tissue soluble specific Staphylococcus Staphylococcus aureus studies subcutaneous substances surface suture Table tion tissue reaction tissue response total joint toxicity Toxicology tumors valve vitro vivo xenobiotic y-globulin