Pharmacokinetics for the Pharmaceutical Scientist

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CRC Press, Apr 20, 1993 - Medical - 336 pages
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Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
  

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Contents

Simple Linear Models
1
More Complicated Linear Models
15
Complicated Linear Models
45
Linear Multicompartment Disposition
63
Noncompartmental and System Analysis
83
Linear Multiple Dose Equations
103
Simple Nonlinear Models
111
OneCompartment Open Model with
126
Physiological Pharmacokinetics
207
Relationship between Physiologically
225
Protein Binding
243
PharmacokineticPharmacodynamic
259
Metabolic Kinetics
269
Laplace Derivation of Linear
281
Measures of Fit
293
Appendix
299

More Complicated Nonlinear Models
143
Urinary Excretion
151
Absorption Analysis and Bioavailability
159

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Page 306 - Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administration.

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