Pharmacokinetics for the Pharmaceutical Scientist
Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
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Simple Linear Models
More Complicated Linear Models
Complicated Linear Models
Linear Multicompartment Disposition
Noncompartmental and System Analysis
Linear Multiple Dose Equations
Simple Nonlinear Models
OneCompartment Open Model with
Relationship between Physiologically
Laplace Derivation of Linear
Measures of Fit
adinazolam amount of drug applied AUC 0-Inf biexponential Equation bioavailability bolus bolus intravenous C,t data central compartment cimetidine coefficients compartment model concentration-time curve deconvolution diazepam differential equations digoxin diphenhydramine disposition parameters dosage interval drug concentration elimination rate constant Equa equal estimated parameters Exact Loo-Riegelman example excretion extravascular fitted to Equation flunarizine flurbiprofen free drug given by Equation gives Equation Hence HOURS Intrasubject C.V. kinetics L/min labetalol Laplace transforms least squares linear liver metabolism metabolite mg/ml MICHAELIS-MENTEN ELIMINATION Model VIII Model XII Model XXXIX nonlinear ONE-COMPARTMENT OPEN MODEL penicillamine pharmacokinetic physiological plasma concentrations plot prednisolone prednisone protein rate constant ratio renal clearance SCHEME shown in Figure simulated single dose single-dose slope spectinomycin steady steady-state concentration Substituting Table theophylline tion tissue TWO-COMPARTMENT OPEN MODEL urinary Verapamil versus volume of distribution Wagner warfarin written as Equation zero zero-order input