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acetaminophen activity administration afferent amitriptyline anaesthetic analgesic analgesic effect antidepressants aspirin aspirin 650 mg aspirin or acetaminophen Beaver W.T. cancer pain carbamazepine causalgia chronic pain chronic pain patients Clin codeine combination CSCI depression descriptors diagnosis diflunisal disease disorder doses of aspirin duration electrodes evaluation evoked factors fibres Figure hydrochloride hydrocodone ibuprofen imipramine increase infusion injection intrathecal levorphanol lipid solubility medication membrane methadone methods migraine mild analgesics morphine muscle contraction headaches naproxen narcotics nerve neuralgia neurons NSAIDs onset oral surgery oral surgery pain oxycodone pain behaviors pain intensity pain management pain problem pain relief patients with chronic pentazocine peripheral phenothiazines physical placebo post-herpetic postoperative pain potential propoxyphene psychiatric psychological receptor reflex sympathetic dystrophy reported response significant Sjolund B.H. skin sodium channel spinal cord spinal opioids stimulation sublingual supraspinal sympathetic blockade symptoms syndrome Table techniques therapy Time-effect curves tocainide treatment tricyclics usually zimelidine