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Human Neutral Endopeptidase 24 11 NEP Enkephalinase
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acute phase acute renal failure amino acid animals antibodies aprotinin assay Bieth Biochem Biol blood buffer cancer cathepsin G Chem chymotrypsin Clin clinical collagen complex concentration correlation creatinine culture decreased disease effect Eglin elastin elevated enzyme factor H fractions function glomerular granulocyte Heidland hemodialysis hepatocytes Horl human increased incubated inhibition injury insulin interleukin-1 intracellular kidney leukocyte elastase Leupeptin liver LNPI lung lysosomal macrophages metabolism method mice molecular weight monocytes muscle protein neutrophil elastase ng/ml normal pancreatic patients peptide peritonitis Physiol plasma levels plasma membrane plasminogen poly G protease activity protein breakdown protein catabolism protein degradation protein synthesis protein turnover proteinase inhibitor proteolysis proteolytic proteolytic activity proximal tubule pulmonary purified rabbit Redl release role sepsis septic serum PSTI significant skeletal muscle SLPI specific stimulated studies substrate supernatants Table tissue trauma trypsin inhibitor uremia values vitro vivo