Neuropsychology of HIV Infection, Issue 494
Igor Grant, Alex Martin
Oxford University Press, 1994 - Medical - 385 pages
The human immunodeficiency virus (HIV) commonly enters the central nervous system, disturbs brain function, and ultimately results in serious brain damage. The most dangerous manifestation of this infection of the brain is HIV-associated dementia, which includes extreme memory loss, slowness in thinking, disorientation, and social incapacity. Most persons who are HIV-infected do not develop severe dementia; however, perhaps 50% of those with AIDS and a smaller proportion of HIV-infected carriers suffer from more subtle brain disorders that can be revealed by proper neuropsychological testing. This ground-breaking volume is the first to summarize the current state of knowledge about the neurocognitive disorders associated with HIV-1 infection. With contributions from leading authorities in the field, the book fully discusses the prevalence, qualitative features, natural course, and effects of neuropsychological impairments in persons with HIV infection. Neuropsychological data are related to findings from studies of brain imaging, neuropathology, and the effects of antiretroviral treatments. This critical work will be essential for neuropsychologists, infectious disease physicians, neurologists, and all those involved in AIDS research and treatment.
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Neurological and Neuropathological Manifestations of HIV Infection
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abnormalities acquired immune acquired immunodeficiency syndrome AIDS dementia complex AIDS patients AIDS-related AIDS-related complex Annals of Neurology Archives of Neurology assessment asymptomatic atrophy basal ganglia behavioral Belman brain Brouwers cells central nervous system cerebral cerebrospinal fluid changes clinical ratings cognitive impairment controls correlation cortical criteria deficiency syndrome deficits depression disorders drug dysfunction effects encephalitis encephalopathy England Journal Epstein factors Heaton HIV disease HIV infection HIV-associated HIV-related HIV+ subjects human immunodeficiency virus imaging immunodeficiency virus infection individuals IVDUs Journal of Medicine lesions lymphocytes lymphoma macrophages McArthur measures memory methylphenidate motor myelopathy Navia neurobehavioral neurocognitive neurological neuronal neuropathy neuropsychological impairment neuropsychological performance neuropsychological tests normal opportunistic infections pathology patients with AIDS pediatric progressive psychiatric quinolinic acid reported rhesus macaque scores seropositive significant specific stages studies subcortical symptomatic HIV symptoms tasks therapy toxoplasmosis treatment viral white matter zidovudine