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EPR Studies on the Mechanism of Biotransformation of Tricyclic
Charge Transfer Interactions of Chlorpromazine with Neural
The Molecular Structure of Phenothiazine Derivatives
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absorption acetylcholine acid activity adenyl cyclase administration albumin animals assay behavior binding blood brain butaperazine butyrophenone C. J. Carr cells chlorpromazine chromatography chronic clinical Clozapine complex compounds concentration correlation cyclic AMP decrease derivatives dopamine dosage dose effect of CPZ electron enzyme excretion extrapyramidal ﬁndings ﬁrst ﬁve ﬂuphenazine Forrest haloperidol hydroxylation imipramine increase incubation indicated inhibition inhibitors injection interaction liver membrane metabolism metabolites metaraminol method mg/kg microsomal mitochondria molecule neuroleptics neurons nitrogen observed ofthe oxidation oxygen patients peak perazine perphenazine phenothiazine physostigmine pigmentation piperacetazine piperazine plasma levels present promazine protein rabbit radioactivity rats Raven Press reaction samples schizophrenic serum side chain signiﬁcant signiﬁcantly solution solvent speciﬁc spectra studies sulfoxide symptoms Table tardive dyskinesia temperature therapeutic therapy thiazines thioridazine thiothixene thioxanthene tion tissue treatment tricyclic uptake urine USA Dr Usdin zine