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abnormal bleeding acid activity added hemolysate adsorbed agent anemia anticoagulant aspirin aspirin tolerance test autosomal basic bleeding episodes bleeding tendency blood clotting blood coagulation bocytopenia capillary cause Clin clinical clot retraction clotting factor concentration of factor consumption-coagulopathy deficiency diagnosis Dicumarol drug effect epistaxis erythrocytes established factor VIII fibrin fibrinogen fresh frozen plasma gastrointestinal bleeding genetic hemophilia hemophilic Hemorrhagic Diseases hemostasis hemostatic hemostatic defects heparin hereditary hypoprothrombinemia injection intravascular clotting intrinsic laboratory lack lesions measured mechanism mild minutes normal nosebleeds observed occurs one-stage prothrombin patient plasma transfusion platelet clotting factor platelet count prolonged bleeding prothrom prothrombin consumption test Purpura fulminans Quick reaction reagent reported salicylate seconds serum severe sickle cell soybean phospholipids surgery syndrome telangiectasia telangiectatic trait test tube therapeutic throm thrombin thrombocytopenia thrombopathy thrombophlebitis thrombosis tion tissue thromboplastin tourniquet test treatment vascular venous vitamin Willebrand's disease